antiprotozoal Flashcards

1
Q

dystentery caused byintestinal invasion of the trophozoite tsage of protozoan entamomeba histolytica

A

amebiasis

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2
Q

type of mosquito that is essential to the life of plasmodium, inject protozoa into humans for further maturation

A

anopheles mosquito

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3
Q

syndrome of quinine toxocity characterized by nausea, vomitting, tinnitus, vertigo

A

chichonism

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4
Q

protozoal intestinal infection that causes severe diarrhea and epigastric distress, may lead to serious malnutrition

A

giardiasis

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5
Q

skin, mucous memebrane, or visceral infection caused by protozoan passed by humans by the bites of sand flies

A

leishmaniasis

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6
Q

protozoal infection with plasmodium, characterized by cycllic fever and chills as the parasite is released from rupture red blood cells, causes serious liver, cns, heart and lung damage

A

malaria

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7
Q

protozoan that causes malaria to humans

A

plasmodium

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8
Q

oppurtunistic infection that occurs when the immune system is depressed, a frequent cause of pneumonia in patient with AIDS and in those who are receiving immunosupressive therapy

A

pneumocystis jiroveci pneumonia

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9
Q

single celled organism that pass through several stages in thier life cycle, including atleast one phase as a human parasite

A

protozoa

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10
Q

found on areas with poor sanitatin hygiene, crowded living condition

A

protozoa

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11
Q

infestation with protozoan that causes vaginitis in women but no sign and syntoms for men

A

trichomoniasis

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12
Q

a developing stage of parasite, which uses the host for essential nutrients needed for growth

A

trophozoite

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13
Q

african-sleeping sickness, which is caused by protozoan that inflames the CNS and is spread to humans by the bite of tseste fly

A

trypanosomiasis

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14
Q

african-sleeping sickness is caused by a fly called

A

tseste fly

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15
Q

chaga’s disease is caused by a fly called

A

house fly

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16
Q

drugs for antimalaria (ppqcm)

A
primaquine
pyrimethamine
quinine
chloroquine
mefloquine
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17
Q

drugs for other antiprotozoal (manpt)

A
metronidazole
atovaquone
nitazoxanide
pentamidine
tinidazole
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18
Q

informal termed for a single celled eukaryotes

A

protozoa

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19
Q

one celled organism like bacteria, but they are bigger than bacteria and contain nucleaus and other strucure , mire like an animal than a plant cell

A

protozoa

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20
Q

protozoa loves moisuture T OR F

A

t

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21
Q

characteristics of protozoa

A
  1. all protozoa are heterotrophic
  2. doesnt have rigid cell wall, but have elastic membrane that permits movement
  3. produces asexually (binarymultiple fission)
    4.
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22
Q

what is heterotrophic

A

they derived their nutrients from other organism by consuming their organic remains

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23
Q

what are the 4 groups of protozoa

A
  1. amoeboid protozoan/sarcodines
  2. flagellated /zooflagellate
  3. ciliated protozoan
    4, sporozoan
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24
Q

what group of protozoan that have examples such like

  • amoeba dysentery
  • entamoeba hystolitica
  • entamoeba gingivalis
A

amoeboid protozoan

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25
Q

what group of protozoan that lives at the termite intestine

A

flagellated

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26
Q

what group of protozoan that have examples such like

  • vorticella
  • balantidium coli
A

cilliated protozoan

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27
Q

what group of protozoan that have examples such like

-plasmodium spp

A

sporozoan

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28
Q

malaria is an insect bite from

A

anopheles mosquito that has plasmodium

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29
Q

trypanosomiasis is a bite from:

A

tsestse fly

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30
Q

leishmaniasis bite from

A

sand fly

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31
Q

protozoal intestinal infection that causes severe diarrhea amd epigrastric distress leading to serious malnutrition

A

giardiasis

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32
Q

protozoan causes vaginitis in women

A

trichomoniasis

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33
Q

type of malaria: the most dangerous type of protozoan

A

plasmodium falciparum

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34
Q

type of malaria: milder form of disease, seldom results in death

A

plasmodium vivax

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35
Q

type of malaria: tropical countries, mild syntoms

A

plasmodium malariae

36
Q

type of malaria: rarely seen, process of being eradicated

A

plasmodium ovale

37
Q

antimalarial actions of various stages stages: acting againts the RBC phase of the life cycle

A

schizontocidal

38
Q

antimalarial actions of various stages stages: acting againsts the gametocyctes

A

gamitocidal

39
Q

antimalarial actions of various stages stages: acting againts the parasite that are developing in the mosquito or work againsts tissue shizonts as prophylactic

A

sporontocidal

40
Q

what are the different antimalarial actions of various stages stages:

A

schizontocidal
gametocytocidal
sporontocidal

41
Q

site of action: what does sporontocidal drugs do in the life cycle of mosquitos/ cycle of humans?

A

active againsts the parasite developing in the mosquito

42
Q

what are the sporontocidal drugs?

A
  • pyrimethamine

- primaquine

43
Q

site of action: what does gametocytocidal drugs do in the life cycle of mosquitos/ cycle of humans?

A

active againsts the gametocytes of all malaria parasites

44
Q

what are the gametocytocidal drugs

A

primiquine

45
Q

what are the gametocyte-sterilizing drugs

A

pyrimethamine

46
Q

site of action: what does schizontocidal drugs do in the life cycle of mosquitos/ cycle of humans?

A

active againsts the erythrocytic phase

47
Q

what are the schizontocidal drugs

A

pyrimethamine

hydroxychloroquine

48
Q

site of action: what does antirelapse drugs do in the life cycle of mosquitos/ cycle of humans?

A

secondary tissue schizont in liver cell

49
Q

what are the antirelapse drugs drugs

A

primaquine

50
Q

site of action: what does causal prophylactic drugs drugs do in the life cycle of mosquitos/ cycle of humans?

A

primary tissue schizont in liver cell

51
Q

what are the causal prophylactic drugs

A
  • pyrimethamine

- primaquine

52
Q

sign and syntoms of malaria

A

related to the destruction of RBC and toxicity of liver

53
Q

treatment of malaria

A

aims to attacking the parasite at the various stages of its development inside and outside of the human body

54
Q

types of antimalarial drugs in relation to the stages in the plasmodium life cycle

A

pic sa page 186

55
Q

use of antiprotozoal therapay across lifespan:

children

A

verysensitive and more severe reaction

56
Q

use of antiprotozoal therapay across lifespan:
>adult
> pregnant and nursing women
> older adult

A

a: need of prophylaxis and immediate treatment
p and n: benefits outweight its risk
o: more suspectible to adverse effects

57
Q

what are the antimalarial drugs?

A
chloroquine
mefloquine
primaquine
pyrimethamine
quinine
58
Q

the mainstay of antimalarial therapy

A

chloroquine

59
Q

prevention and treatment of plasmodial malaria; treatment of extraintestinal amebiasis

A

chloroquine

60
Q

treatment of plasmodial malaria in combination with other drugs (particulary primaquin)

A

hydroxychloroquine

61
Q

what antimalarial drugs for prevention and treatment of plasmodium malaria; treatment for extraintestinal amebiasis

A

chloroquine

62
Q

what antimalarial drugs for prevention and treat,ent for plasmodium malaria in combination with other drugs

A

mefloquine

63
Q

what antimalarial drugs for prevention of relapses of plasmodium vivax and plasmodium malariea ; radical cure of P. vivax malaria

A

primaquine

64
Q

prevention of plasmodium malaria in combination with other agents to supress transmission; treatment of toxoplasmosis

A

pyrimethamine

65
Q

treatment of uncomplicated malaria caused by plasmodium falciparum

A

quinine

66
Q

treatment for chloroquine resistant plasmodial infection

A

quinine

67
Q

what is the antimalarial indication

A

to prevent acute malarial reaction in individuals who have been infected by the parasite

68
Q

what is the antimalarial action

A

ebter human red blood cells and change metabolic pathway necessary for reproduction

69
Q

intestinal infection caused by entamoeba histolytica known as amebic dysentery

A

amebiasis

70
Q

an infection where the sand fly inject an asexual form flagellated protozoan called promastigote but digested by macrophage, but inside the macrophage it develops into amastigote that will eventually kill macrohage and it will releseas and another macrophage will eat then then same cycle again

A

leishmaniasis

71
Q

amastigote causes lesions in skin, viscera, mucuous membrane of host

A

amastigote

72
Q

caused by trypanosoma

A

trypanosomiasis

73
Q

____-african sleeping , sickness caused by ____live in blood then attacks CNS , leads to acute inflammation leads to lethargy , prolomged sleep, death

A

trypanosomiasis; tseste fly

74
Q

when individuals have aids they are immunosupressed then parasite able to infect lungs leading to severe inflammation knowns as

A

pneumocystis jiroveci pneumonia

75
Q

preventon and treatment for pneumocystis jiroveci pneumonia and combination iwht chloriquine

A

atovaquone

76
Q

treatment for amebiasis, trichomonaiasis, giardiasis

A

metronidazole

77
Q

treatment of diarrhea asssoiated with guardia lamblia

A

nitrazoxanide

78
Q

an inhalation treatment for pneumocystis jiroveci

and systemic agent treatment of trypanosomiasis and leishmaniasis

A

pentamidine

79
Q

treatment for trichomoniasis, giardiasis, amebiasis

A

tinidazole

80
Q

what are the common antiprotozoal agents:

np mt a

A
81
Q

what chloroquine do inside the parasite?

A

metabolic pathway

82
Q

what mefloroquine do inside the parasite?

A

acidic protzoal vacuole food

83
Q

what do inside the primaquinine parasite?

A

mitochondria, gametocyte, exocrythrocytic

84
Q

what do inside the pyramethamine parasite?

A

folic acid

85
Q

what do inside the quinine parasite?

A

glucolis, nucliec and protein synthesis