Antiplatelet Drugs Flashcards
Is aspirin proven to be beneficial in the primary or secondary prevention of CVD?
Secondary.
What is dipyridamole licensed for?
The secondary prevention of ischaemic stroke and TIA.
What is prasugrel or ticagrelor, in combination with aspirin, licensed for? How long are they used for?
Acute coronary syndrome, usually given for 12 months.
What age group should aspirin use be avoided in? Why?
Patients under 16 due to the risk of Reye’s syndrome.
What are some symptoms commonly associated with Reye’s syndrome?
Vomiting, fatigue, seizures.
What red flag symptoms associated with oral antiplatelet use, should be immediately referred to a doctor?
Chronic GI bleeding (severe abdominal pain, vomiting blood, black/red stool), haemorrhage, hypersensitivity (aspirin), heaviness in the chest, pregnancy, breastfeeding.
What monitoring is required when a patient is on antiplatelet?
Renal and hepatic function.
After how long should MR dipyridamole capsules be discarded?
Six weeks.
When should antiplatelets (apart from dipyridamole) be taken?
With or after food.
When should dipyridamole be taken?
30-60 minutes before food.
Use of which drugs may reduce the antiplatelet activity of clopidogrel?
Carbamazepine, cimetidine, ciprofloxacin, erythromycin, fluconazole, fluoxetine, itraconazole, ketoconazole, oxcarbazepine, moclobemide, lansoprazole, pantoprazole, rabeprazole, etravirine.
Use of clopidogrel enhances the anticoagulant effect of which drugs?
Coumarins and phenindione.
Clopidogrel increases the plasma concentration of which drug?
Rosuvastatin.
Dipyridamole increases the effects of which drugs?
Adenosine, coumarins, phenindione, heparin.
Use of antiplatelet drugs with which drugs is associated with an increased risk of bleeding?
Other antiplatelets, NSAIDs, SSRIs, methotrexate, anticoagulants.
