Antiplatelet Agents

Question 1

What is the action?

Answer 1

Block the receptor site on the platelet membrane which prevents platelets from sticking together & clumping

Question 2

Antiplatelet agent drug names?

Answer 2

Aspirin
Ticagrelor
Eptifibatide
Clopidogrel
Dipyridamole

Question 3

Antiplatelet contraindications

Answer 3

Allergy
pregnancy
lactation

Question 4

Antiplatelet Caution

Answer 4

Bleeding disorders
Recent Surgery
Closed-head injury

Question 5

Antiplatelet drug-drug interactions

Answer 5

Another drug that affects blood clotting (↑ risk of bleeding)
CYP3A inhibitors or inducers (liver isoenzyme) metabolizes many drugs

Question 6

Antiplatelet indications (use for)

Answer 6

CV disease that are prone to clogged vessels
keep grafts open/patent
prevent cerebrovascular occlusion (strokes & TIAs)
Adjunct to thrombolytic therapy after MI & to prevent another MI
Aspirin: anti-inflammaroty, analgesic & antipyretic effects

Question 7

Antiplatelet agents adverse effects

Answer 7

Bleeding
CNS: headache, dizziness, and weakness
GI distress

Question 8

Antiplatelet agents nursing implications

Answer 8

Good Hx
Contraindications/cautions
baseline physical; to get a baseline
Vital Signs, Heart, lung sounds, skin
CNS perfusion (pulses)
Labs: for clotting
Risk for injury
Acute pain
small frequent meals for GI upset
Safety measures: use electric razor, soft bristle toothbrush, avoid contact sports
Apply pressure on IV site
Response to drug
Monitor compliance with the regimen
Preventing clot events, evaluate for ↑ bleeding time

Question 9

Antiplatelet agent prototype

Answer 9

Aspirin

Question 10

Aspirin Action

Answer 10

inhibits platelet aggregation by inhibiting platelet synthesis of thromboxane A2

Question 11

Aspirin Indications

Answer 11

↓ risk of current TIAs or strokes in men with a hx of TIA due to fibrin or platelet emboli
Reduction of death or nonfatal MI in patients with a hx of infarction or unstable angina & MI prohylaxis
Has anti-inflammatory analgesic & antipyretic effects

Question 12

Aspiring adverse effects

Answer 12

Acute aspirin toxicity with hyperpnea
possibly leading to fever
coma and cv collapse
Nausea, dyspepsia
heartburn epigastric
discomfort
GI bleeding, occult blood loss
Dizziness, tinnitus
difficulty hearing & anaphylactoid reaction