Antiphospholipid Syndrome Flashcards
1
Q
Antiphospholipid Syndrome
A
= acquired disorder characterised by predisposition to both venous and arterial thromboses, recurrent fetal loss and thrombocytopenia
May occur as primary disorder or secondary to other conditions, most commonly SLE
2
Q
Antiphospholipid Syndrome - Cx in Pregnancy
A
- Recurrent miscarriage
- IUGR
- Pre-eclampsia
- Placental abruption
- Pre-term delivery
- VTE
NB Antiphospholipid antibodies (aPL) are present in 15% of women w recurrent miscarriage
3
Q
Antiphospholipid Syndrome - Mx in Pregnancy
A
Mx:
- Low dose Aspirin once pregnancy confirmed on urine testing
- LMWH once foetal heart is seen on US
- Usually discontinued at 34 weeks gestation
- These interventions increase live birth rate seven fold
