ANCA

Question 1

ANCA

Answer 1

There are 2 main types of anti-neutrophil cytoplasmic antibodies (ANCA)
cANCA = Cytoplasmic
pANCA = Perinuclear

Question 2

cANCA vs pANCA

Answer 2

For exams:
cANCA = Wegener’s granulomatosis
pANCA = Churg-Strauss syndrome

Question 3

cANCA

Answer 3

• Wegener’s granulomatosis +ve in >90%

- Microscopic polyangiitis +ve in 40%

Question 4

pANCA

Answer 4

• Immune crescentic glomerulonephritis +ve in 80%
• Microscopic polyangiitis +ve in 50-75%
• Churg-Strauss syndrome +ve in 60%
• PSC +ve in 60-80%
• Wegener’s granulomatosis +ve in 25%

Question 5

Other causes of +ve ANCA (usually pANCA)

Answer 5

• Autoimmune hepatitis
• IBD
• UC >Crohns
• CTDs - RA, SLE, Sjogren’s