Antineoplastics 2 Flashcards
1
Q
What do Alkylating agents do?
A
Cross-link DNA and cause damage
2
Q
What is the common property among chemotherapeutic alkylating agents?
A
The formation highly reactive carbonium ion intermediates.
3
Q
What atoms in guanine are reactive to alkylating agents?
A
- N7 (particularly susceptible)
- O6
4
Q
What atoms in adenine ring are reactive to alkylating agents?
A
- N1 and N3
5
Q
What atoms in cytosine are reactive to alkylating agents?
A
N3
