Antineoplastic Flashcards
The branch of medicine concerned with the study of malignancy-development, dx, tx, and prevention is defined as:
Oncology
Pertaining to a substance, procedure, or measure that prevents proliferation of cells is defined as:
antineoplastic
The pharmaceutical agents used to destroy CA cells are defined as:
antineoplastics or cytoxic drugs
What phase of the cell cycle is not as sensitive to antineoplastic Tx as the other phases of the cell:
Go
What type of cells arise from a single abnormal cell that multiplies and grows:
CA cells
What happens as abnormal cells continue to divide:
They lose some of their original characteristics
What are the characteristics of CA cells:
anaplasia; autonomy; metastasis; angiogenesis
The loss of cellular differentiation and organization is defined as what type of CA characteristic:
anaplasia
To grow in an uninhibited way/manner is defined as what type of CA characteristic:
autonomy
The ability to travel to other sites of the body is defined as what type of CA characteristic:
metastasis
The ability to grow new bld vessels to feed a tumor is defined as what type of CA characteristic:
angiogenesis
What are the specific protocols used before giving chemotherapy to pts:
type/extent of malignancy; type of chemo given; side effects; amount of time normal cells need to recover=giving the chemo in cycles
What are the major factors that affect the CA cells response to chemotherapy:
Growth fraction and doubling time
The percent of actively dividing cells is defined as:
growth fraction
The time it take the cell to double in size is defined as:
Doubling time/growth rate
Anticancer drugs are most effective on CA cells d/t what major factor:
Cells with high growth fraction
Antineoplastic/Anticancer drugs treat malignancies by directly killing tumor cells how:
Damaging the DNA; inhibiting DNA synthesis from replication; stoping mitosis
Antineoplastic drugs destroy CA cells by inhibiting cell division but also affect normal cells. What type of normal cells do they affect the most:
Rapidly multiplying cells or cells that replaces themselves quickly; thus, causing side effects
This type of chemotherapy is used to relieve S/S associated with advanced CA (pain, breathing…) and improve quality of life is defined as:
palliative chemotherapy
This category of antineoplastic drugs exert their influence during a specific phase of the cell cycle; are the most effective against rapidly growing CA cells is defined as and what are the examples:
CCS (cell-cycle specific or cell-cycle dependent); antimetabolites and mitotic inhibitors
This category of antineoplastic drugs exert their influence during any phase of the cell cycle, especially the Go phase is defined as and what are the examples:
CCNS (Cell-cycle nonspecific or cell- cycle independent); alkylating; anti-tumor antibiotics; hormones
The combined use of CCS and CCNS drugs maximize cell death is defined as:
synergistic effect
The synergistic effect of the combination of CCS and CCNS is:
Kills cells in all phases of the cell cycle, especially the cells that have a high fraction rate; decreases drug resistance and increases destruction of CA cells
What are the causes of MDRL:
Cell mutation; natural resistance; gene amplification; repair DNA damage
What are the specific classes of chemotherapy drugs:
alkylating agents; antimetabolites; anti-tumor antibiotics; plant alkaloids; Miscellaneous agents
Alkylating agents are of the CCNS category, but what phase are they most effective on:
Go phase d/t slow-growing CA which may have cells in the resting phase
What is the mechanism of action brought upon by alkylating agents:
Inhibits DNA synthesis by binding and damaging the DNA which prevents the cell from dividing
What is the main type of alkylating agent given for Tx:
Cytoxan (cyclophosphamide)
What are the pharmacokinetics of Cytoxan:
50 PERCENT IS EXCRETED UNCHANGED IN THE URINE; onset =2-3 hrs; therapeutic effect takes several days
What are the adverse effects of Cytoxan:
HEMORRHAGIC CYSTITIS (give >500 mL of fluid prior); BONE MARROW SUPPRESSION; 2dary malignancies (secondary neoplasm), sterility
What are the Cytoxan major dose-limiting toxicities:
Hematopoietic system and urinary system
Cytoxan is contraindicated to pts with:
pregnant; bone marrow suppression; impaired renal/hepatic function
What may occur if I take Allopurinol or HTCZ w/Cytoxan?
Increased bone marrow suppression
What may occur if I take Phenobarbital with Cytoxan:
Cytoxan toxicity increases
What may occur if I take Cytoxan with Warfarin or ASA (NSAIDs):
bleeding
What may occur if I take Digoxin with Cytoxan:
Cytoxan will decrease digoxin effects
An accumulation of toxic metabolites that causes inflammation of the bladder (may be painless) and bleeding in the urine is a result is defined as:
hemorrhagic cystitis (MUST HYDRATE BEFORE GIVING CYTOXAN)
Cytoxan should be taking early in the morning why and what should be avoided in the diet during Cytoxan Tx:
avoid accumulation in the bladder at night; avoid high purines (beans/peas/organ meats) to alkalinize the urine. avoid citric acid
Bone marrow suppression include:
Low RBC (anemia); low WBC (neutropenia); low platelet count (thrombocytopenia)
Antimetabolites are S phase specific with the exception of what type of antimetabolite drug:
5-FU adrucil (fluoroacil) is considered both CCNS and CCS
What is the therapeutic action of antimetabolite drugs:
Disrupts the metabolic process and inhibits enzyme synthesis which prevents normal cellular function
Antimetabolites are often given with other agents to…
help overcome MDR tumors
5-FU Adrucil is contraindicated in pts with:
GI ULCERATIONS/DISEASES; pregnant; bone marrow suppression; renal/hepatic disfunction
What are the adverse effects of antimetabolite drugs:
STOMATITIS; BONE MARROW SUPPRESSION (LIFE-THREATENING INFECTIONS/BLEEDING); hepatic/renal dysfunction
What is the action of 5-FU adrucil:
prevention of thymidine synthase production, thus inhibiting DNA/RNA synthesis
What are the adverse effects of 5-FU adrucil:
STOMATITIS: may be early sign of 5-FU toxicity
What may occur if I take Leucovorin calcium with 5-FU adrucil:
increases 5-FU toxicity
What may occur if I take Metronidazole with 5-FU adrucil:
increases 5-FU toxicity
What may occur if I take HTCZ with 5-FU adrucil:
increases myelosuppression (decrease in blood cell production)
Soreness, ulcerations, and white patches of the mouth is defined as:
stomatitis (Can use NS to rinse mouth out every 2 hrs/avoid mouthwashes)
Anti-tumor antibiotics are CCNS drugs with the exception of:
bleomycin (Blenoxane) EFFECTS G2 PHASE
What is the action of anti-tumor antibiotics:
inhibits protein/RNA synthesis and binds to DNA causing FRAGMENTATION
What are the main two types of anti-tumor antibiotics:
bleomycin (G2 specific) and Doxorubicin (CCNS)
What is the adverse effect of Doxorubicin:
CARDIOTOXIC EFFECTS
What are the common side effects of anti-tumor antibiotics:
mucositis, N/V; CARDIOTOXIC EFFECTS
How should anti-tumor antibiotics be given:
very slowly if pt has a congestive heart (pts’ cardiovascular system-EKG- should be assessed prior to administering drug)
What other drug is given along with Doxorubicin to reduce cardiac symptoms:
Dextrazoxane (Zinecard)
Plant alkaloids are mitotic inhibitors CCS. What is their action:
Blocks cell division at the M phase of the cell cycle
What are the adverse reactions of plant alkaloids mitotic inhibitors:
NEUROTOXICITY=PERIPHERAL NEUROPATHY; leukopenia; loss of DTR
What are some examples of plant alkaloids mitotic inhibitors:
Vincristine (Oncovin)
What are the adverse reactions of Vincristine (oncovin):
SENSORY LOSS; NEUROPATHY=PERIPHERAL NEUROPATHY; extravasation; hypoNA; ILEUS
Wha are some life-threatening effects of Vincristine (Oncovin):
intestinal necrosis; SZ; coma; bronchospasm; bone marrow suppression