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Antimicrobial Pharmacotherapy > Antimycotics > Flashcards

Antimycotics Flashcards

1
Q

Onychomycosis

A

Terbinafine
Intraconazole

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2
Q

Cryptococcal meningitis

A

Flucanozole
Amphoteracin B

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3
Q

Oropharyngeal candidiasis

A

Nystatin
Fluconazole

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4
Q

Invasive Aspergillosis

A

Vornicazole

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5
Q

Mucomycosis

A

Isacuvonazole

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6
Q

Tinea Versicolor

A

Ketaconazole

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7
Q

Antimycotic that inhibits alpha demethylase causing a decrease in ergosterol

A

Azoles

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8
Q

Antimycotic that bind to egosterol forming pores

A

Polyenes

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9
Q

Terbinafine MOA

A

inhibition of squalene causing a decrease of ergosterol

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10
Q

MOA of Caspofungin

A

Inhibits beta glucan

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11
Q

Antimycotic that can cause reversible alopecia

A

Fluconazole

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12
Q

Azole to most commonly cause Hepatoxicity

A

Itraconazole

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13
Q

Other functions of Ketoconzole

A

Prostate cancer
Psoriasis
Hypercotisolism
Hurtism

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14
Q

Azole that May cause adrenal Cortez insufficiency

A

Ketaconazole

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15
Q

Indications of Miconazole

A

Topical fungical infections
- vaginal candidiasis
- Tinea versicolor

Oropharyngeal candidiasis

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16
Q

Drug of choice for Histoplasmosis

A

Itraconazole

17
Q

Drug of choice for Blastomycosis

A

Itraconazole

18
Q

Px that after visit to a bat cave starts with a fungal infection, which Antimycotic do you use?

A

Itraconazole
(Coccidomycosis)

19
Q

Antimycotic that can lead to fatal cardiac arrhythmias if combined with malaria tx and heroin addiction Tx

A

Itraconazole

20
Q

T or F: Fluconazole has greater spectrum than Itraconazole

A

F

21
Q

Onychomycosis Antimycotic that is contradicted in pregnant women

A

Itraconazole

22
Q

Antimycotic used for salvage therapy vs Aspergillosis

A

Caspofungin
Posaconazole

23
Q

Azole related to cause visual disorders ( photosensitivity and blurry vision)

A

Vornicazole

24
Q

Adverse effects caused by the systemic use of azoles

A

Hepatotoxic
GI upset
QT prolongation
Hypokalemia
Gynecomastia

25
Q

Contraindications for Azole use

A

Cardiac arrhythmias
Severe cardiac insufiency
PPIs ( Azoles requiere low ph to be absorbed)

26
Q

Antimycotic that can cause Stevens-Johnson’s Syndorme

A

Fluconazole
Nystatin
Terbinafine

27
Q

Adverse effects of Amphoteracin B

A

Nephrotoxicity
Arrythmias
IV phlebitis
“Shake and bake” = fever and chills

28
Q

Antimycotic that causes fever and chills (shake and bake)

A

Amphoteracin B

29
Q

Dermatophysis or “Ringworm”

A

Ketoconazole

(Athletes foot)

30
Q

T or F: Nystatin only is active vs. Cándida

A

T

31
Q

What is the only indication of Keroconazole

A

Candidiasis

32
Q

Antimycotic drug that causes flushing

A

Caspofungin

Antimicrobial Pharmacotherapy (4 decks)

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