Antimycotics Flashcards
Onychomycosis
Terbinafine
Intraconazole
Cryptococcal meningitis
Flucanozole
Amphoteracin B
Oropharyngeal candidiasis
Nystatin
Fluconazole
Invasive Aspergillosis
Vornicazole
Mucomycosis
Isacuvonazole
Tinea Versicolor
Ketaconazole
Antimycotic that inhibits alpha demethylase causing a decrease in ergosterol
Azoles
Antimycotic that bind to egosterol forming pores
Polyenes
Terbinafine MOA
inhibition of squalene causing a decrease of ergosterol
MOA of Caspofungin
Inhibits beta glucan
Antimycotic that can cause reversible alopecia
Fluconazole
Azole to most commonly cause Hepatoxicity
Itraconazole
Other functions of Ketoconzole
Prostate cancer
Psoriasis
Hypercotisolism
Hurtism
Azole that May cause adrenal Cortez insufficiency
Ketaconazole
Indications of Miconazole
Topical fungical infections
- vaginal candidiasis
- Tinea versicolor
Oropharyngeal candidiasis
Drug of choice for Histoplasmosis
Itraconazole
Drug of choice for Blastomycosis
Itraconazole
Px that after visit to a bat cave starts with a fungal infection, which Antimycotic do you use?
Itraconazole
(Coccidomycosis)
Antimycotic that can lead to fatal cardiac arrhythmias if combined with malaria tx and heroin addiction Tx
Itraconazole
T or F: Fluconazole has greater spectrum than Itraconazole
F
Onychomycosis Antimycotic that is contradicted in pregnant women
Itraconazole
Antimycotic used for salvage therapy vs Aspergillosis
Caspofungin
Posaconazole
Azole related to cause visual disorders ( photosensitivity and blurry vision)
Vornicazole
Adverse effects caused by the systemic use of azoles
Hepatotoxic
GI upset
QT prolongation
Hypokalemia
Gynecomastia
Contraindications for Azole use
Cardiac arrhythmias
Severe cardiac insufiency
PPIs ( Azoles requiere low ph to be absorbed)
Antimycotic that can cause Stevens-Johnson’s Syndorme
Fluconazole
Nystatin
Terbinafine
Adverse effects of Amphoteracin B
Nephrotoxicity
Arrythmias
IV phlebitis
“Shake and bake” = fever and chills
Antimycotic that causes fever and chills (shake and bake)
Amphoteracin B
Dermatophysis or “Ringworm”
Ketoconazole
(Athletes foot)
T or F: Nystatin only is active vs. Cándida
T
What is the only indication of Keroconazole
Candidiasis
Antimycotic drug that causes flushing
Caspofungin
