antimuscarinics for PD

Question 1

procyclidine - how does it exert its antiparkinsonian action

Answer 1

by reducing the effects of the relative central cholinergic excess that occurs as a result of dopamine deficiency

Question 2

3 indications of procyclidine

Answer 2

• parkinonism
• drug induced extrapyramidal symptoms (but not tardive dyskinesia)
• acute dystonia

Question 3

when is procyclidine contraindicated

Answer 3

GI obstruction

Question 4

SE of procyclidine

Answer 4

IT IS AN ANTICHOLINERGIC
constipation
dry mouth
urinary retention
blurred vision

Question 5

trihexyphenidyl - how does it exert its effects?

Answer 5

by reducing the effects of the relative central cholinergic excess that occurs as a result of dopamine deficiency.

Question 6

an indication for Trihexyphenidyl is PD (if used in combo with co-careldopa or co-beneldopa). why is its use not recommended in PD?

Answer 6

because of toxicity in elderly and risk of aggravating dementia

Question 7

Trihexyphenidyl - contraindication

Answer 7

myasthenia gravis

Question 8

Trihexyphenidyl - treatment cessation

Answer 8

Avoid abrupt withdrawal in patients taking long-term treatment.

Question 9

Trihexyphenidyl - directions for administration

Answer 9

tablets should be taken with or after food.