Antimicrobial Chemotherapy Supplementary Deck Flashcards
How do β-lactams work?
Inhibit cell wall synthesis: disrupt peptidoglycan synthesis by inhibiting enzymes responsible for cross linking the carbohydrate chains.
How to glycopeptides work?
Inhibit cell wall synthesis: inhibiting formation of a glycopeptide precursor
Which bacteria are sensitive to glycopeptides?
Gram positive only
Give two examples of glycopeptides
Vacomycin
Teicoplanin
How to aminoglycosides work?
Inhibit protein synthesis
How do macrolides work?
Inhibit protein synthesis
Which bacteria are sensitive to aminoglycosides?
Most staphlococci
Which bacteria are sensitive to macrolides?
Gram positive
How do tetracyclines work?
inhibit protein synthesis
How do oxazolidinones work?
Inhibit protein synthesis
Give an example of an Oxazolidinone
Linezolid (the only one)
What is Linezolid primarily used for?
MRSA infections
How do cyclic lipopeptides work?
Inhibit protein synthesis
Give an example of a cyclic lipopeptide
Daptomycin
What is Daptomycin useful for?
MRSA infections
How does Trimethoprim work?
Inhibits purine synthesis
How does Sulphamethoxazole work?
Inhibits purine synthesis
Why might Co-trimoxazole by considered better than a penicillin?
Less likely to cause C. diff infection
How do fluoroquinolones work?
Inhibit enzymes involved in DNA synthesis
Give an example of a fluoroquinolone?
Ciprofloxacin
Which bacteria are sensitive to ciprofloxacin?
Gram negative only
How do polyenes work?
Binds to ergosterol in the fungal cell wall increasing its permeability
Why are polyenes toxic?
Also bind to cholesterol
Give two examples of polyenes
Amphotericin B
Nystatin
