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Principles of Disease > Antimicrobial Chemotherapy Supplementary Deck > Flashcards

Antimicrobial Chemotherapy Supplementary Deck Flashcards

1
Q

How do β-lactams work?

A

Inhibit cell wall synthesis: disrupt peptidoglycan synthesis by inhibiting enzymes responsible for cross linking the carbohydrate chains.

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2
Q

How to glycopeptides work?

A

Inhibit cell wall synthesis: inhibiting formation of a glycopeptide precursor

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3
Q

Which bacteria are sensitive to glycopeptides?

A

Gram positive only

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4
Q

Give two examples of glycopeptides

A

Vacomycin

Teicoplanin

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5
Q

How to aminoglycosides work?

A

Inhibit protein synthesis

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6
Q

How do macrolides work?

A

Inhibit protein synthesis

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7
Q

Which bacteria are sensitive to aminoglycosides?

A

Most staphlococci

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8
Q

Which bacteria are sensitive to macrolides?

A

Gram positive

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9
Q

How do tetracyclines work?

A

inhibit protein synthesis

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10
Q

How do oxazolidinones work?

A

Inhibit protein synthesis

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11
Q

Give an example of an Oxazolidinone

A

Linezolid (the only one)

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12
Q

What is Linezolid primarily used for?

A

MRSA infections

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13
Q

How do cyclic lipopeptides work?

A

Inhibit protein synthesis

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14
Q

Give an example of a cyclic lipopeptide

A

Daptomycin

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15
Q

What is Daptomycin useful for?

A

MRSA infections

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16
Q

How does Trimethoprim work?

A

Inhibits purine synthesis

17
Q

How does Sulphamethoxazole work?

A

Inhibits purine synthesis

18
Q

Why might Co-trimoxazole by considered better than a penicillin?

A

Less likely to cause C. diff infection

19
Q

How do fluoroquinolones work?

A

Inhibit enzymes involved in DNA synthesis

20
Q

Give an example of a fluoroquinolone?

A

Ciprofloxacin

21
Q

Which bacteria are sensitive to ciprofloxacin?

A

Gram negative only

22
Q

How do polyenes work?

A

Binds to ergosterol in the fungal cell wall increasing its permeability

23
Q

Why are polyenes toxic?

A

Also bind to cholesterol

24
Q

Give two examples of polyenes

A

Amphotericin B

Nystatin

25
Q

How do imidazoles work?

A

Inhibition of ergosterol synthesis

26
Q

Give two examples of imidazoles

A

Miconazole

Ketoconazole

27
Q

How do triazoles work?

A

Inhibit ergosterol synthesis

28
Q

Give three examples of triazoles

A

Fluconazole
Itraconazole
Voriconazole

29
Q

How do allylamines work?

A

Inhibiton of ergosterol synthesis (different stage in pathway to azoles)

30
Q

Give an example of an allylamine

A

Terbinafine

31
Q

How do echinocandins work?

A

Inhibit glucan polysaccharide synthesis

32
Q

Give three examples of echinocandins

A

Caspofungin
Mycafungin
Anidulafungin

33
Q

Which fungi are echinocandins used for and are they fungicidal or inhibitory

A 
Serious:
Candida infections (Fungicidal action)
Aspergillus infections (Inhibition)

Principles of Disease (6 decks)

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