Antimicrobial agents Flashcards
What is Rifampin selective
There is a difference between mammalian and bacterial rna polymerase
what part of the mammalian cell does rifampin effect?
the mt because these have more bacterial transcription systems
what is rifampin used with??
other antibiotics
how is rifampin made?
from soil bacteria
where does rifampin bind?
to a pocket in the beta subunit of rna polymerase in the channel where the DNA is kept this blocks elongation
whart does erythromycin bind to?
the 50s subunits of the ribosome
what is erythromycin made of?
12016 carbon ring
what part of translation does erythromycin block?
translocation
where is erythromycin more effective?
the gram positives
what is a tetracyclin a type of?
macrolide
what does tetracyclin bind to?
the 30s subunit of the ribosome
what does tetracycllin stop?
the binding of the aa tRNA to the ribosome acceptor site
why is tetracyclin not selective but still ok?
it doesnt build up in high enough conc in euk cells to damage euk ribosomes
what type of molecule is kanamycin?
an aminoglycoside
what does kanamycin target?
the 30s subunit of the ribosome
