Antihypertensive Bypass Drug Info Flashcards
0
Q
Nitroglycerine (Nitrobid, Nitrek)
A
Low dose: venous dilation
High dose: arterial dilation
Uses mitochondrial cells to convert to NO
Lowers blood pressure, PCWP, and SVR
Decreases myocardial O2 demand during ischemia without affecting contractility
Dosing is site specific
1
Q
Hydralazine (Apresoline)
A
Arterial»>venous effect
Causes endothelial cells to release NO
Decreases SVR and arterial pressure
Safe for pregnant women and fetuses
2
Q
Nitroprusside (Nipride, Nitropress)
A
Potent arterial and venous dilator Lowers preload and afterload Increases CO in heart failure patients Keep in opaque bag Cyanide toxicity Half life: 1-2min Thiocynate half life: many days
