Antihyperlipidemic Agents Flashcards
1
Q
Chylomicrons
A
- Carry dietary triglycerides from GI to adipose and muscle tissue
2
Q
VLDLs
A
- Carry triglycerides from liver to adipose and muscle tissue
3
Q
LDLs
A
- Carry cholesterol to liver, body tissues, arterial “plaques”
4
Q
HDLs
A
- Carry cholesterol from tissues to liver for elimination
5
Q
Bile Acid-Binding Resins
A
- Resins that bind bile acids/salts in GI to prevent reabsorption, mainly decrease LDL-cholesterol
- Cholestyramine
- Colestipol
- Colesevelam
6
Q
Inhibitors of HMG-CoA Reductase
A
- “Statins”- inhibit liver synthesis of cholesterol, mainly decrease LDL-cholesterol, lesser effect may increase HDL-cholesterol
- Rosuvastatin
- Simvastatin
- Atorvastatin
- Lovastatin
- Pravastatin
7
Q
Ezetimibe
A
- Inhibits intestinal absorption of dietary/biliary cholesterol, decreases LDL-cholesterol
8
Q
Niacin or Nicotinic Acid
A
- Inhibits lipolysis in adipose tissue to decrease formation of FFA and triglyceride synthesis, decreases VLDL-triglycerides and LDL-cholesterol and Lp[a], increases HDL-cholesterol
9
Q
Fibric Acid Derivatives
A
- Increase lipoprotein lipase to decrease VLDL-triglyceride synthesis, some increases in HDL-cholesterol
- Gemfibrozil
- Fenofibrate
