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Pharm 3 > Antihistamines > Flashcards

Antihistamines Flashcards

1
Q

Autacoids

A

Local and sometimes systemic regulators of blood flow and inflammatory process

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2
Q

What class of autacoids are we studying

A

Decarboxylated amino acids

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3
Q

Where is histamine made

A

mast cells, basophils, ECL in GI mucosa, neurons of CNS

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4
Q

Metabolism of histamines

A

Oxidative pathway in liver

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5
Q

What sensitivity does histamine play a role in

A

IgE mediated type I

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6
Q

What kind of drug is cisapride

A

5HT4 and enhance Ach release

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7
Q

What kind of drug is mirtazipine

A

Atypical antidepressant- blocks 5HT2a, 2c, alpha2

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8
Q

What kind of drug is fluoxetine

A

SSRI

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9
Q

What kind of drug is Clomipramine

A

TCA

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10
Q

What kind of histamine is meclizine

A

H1 1st gen

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11
Q

What kind of histamine is cyproheptadine

A

H1 1st gen

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12
Q

What kind of histamine is diphenhydramine

A

H1 first gen

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13
Q

What kind of drug is selegeline

A

Selective MAOb (at higher MAOa as well)

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14
Q

What kind of histamine is famotidine

A

H2

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15
Q

What kind of drug is trazodone

A

5HT2a/2c and weak PreSRI

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16
Q

What kind of drug is ondansetron

A

5HT3 antagonist

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17
Q

First gen vs second gen

A

1st less selective, cross BBB (drowsiness)

18
Q

Diphenhydramine - metabolism

A

liver, metabolites excreted by urine

19
Q

Diphenhydramine - uses

A

Anti-emetic, rhinitis, pruritis, allergic derm

20
Q

Cyproheptadine- uses

A

cat app stim, serotonin syndrome in dogs

21
Q

Meclizine- uses

A

Motion sickness and anti-emetic, vestibular disorders in dogs; CRTZ

22
Q

Function of H2

A

gastric secretion

23
Q

Most potent, longest duration H2 blocker

A

Famotidine

24
Q

Famotidine- metab

A

Liver, first pass substantial, unchanged in urine

25
Q

Where is 5HT found

A

Primarily in GI tissue, some in CNS, platelets

26
Q

Serotonin syndroms- cause/effect

A

Altered serotonin via 5HT receptor- temperature and hemdynamic changes

27
Q

What mediates serotonin degradation

A

MAO

28
Q

Selegeline- MOA

A

selective MAOB

29
Q

Selegeline- uses

A

Canine cognitive dysfunction, cushings

30
Q

Selegeline- SE

A

GI, CNS excitation or lethargy

31
Q

TCA- example

A

Clomipramine

32
Q

Common SE of fluoxetine

A

Appetite reduction/weight loss

33
Q

Mirtazipine- MOA

A

Blocks 5HT2a/2c, a2’s, increase NE transmission

34
Q

Mirtazipine- uses

A

appetite stim, anti-emetic

35
Q

Trazodone- MOA

A

Inhibits 5HT2a/2c and weak pre-synaptic SRI

36
Q

Trazodone- uses-

A

Anxiolytic,

37
Q

Cisapride- MOA

A

5HT4 agonist with Ach release

38
Q

Cisapride- uses

A

Gastric motility, megacolon,

39
Q

Ondansetron- uses

A

anti-emetic dogs

40
Q

Ondansetron- MOA

A

CRTZ action via 5HT3

Pharm 3 (8 decks)

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