Antigen

Question 1

The ability of an antigen to induce an immune response does NOT depend on:

Answer 1

ability to enter the thyroid.

BUT DOES depend on: degree og aggregation, dose, size and usual presence in the body

Question 2

Alum is an effective adjuvant because it:

Answer 2

slows the release of the antigen

Question 3

Antibody corss-reactivity is demonstrated by antigen binding to:

Answer 3

an antigen that is structurally similar to the immunogen

Question 4

The antibiotic penicillum is a small molecule that does not induce antibody formation. However, penicillin binds to serum proteins and forms a complex that in some people induces antibody
formation resulting in an allergic reaction. Penicillin is therefore

Answer 4

both an antigen and a hapten

Question 5

Antigen entering the body in a subcutaneous injection activates its specific lymphocytes in the:

Answer 5

draining lymph nodes

Question 6

To detect a humoral immune response to influenza virus, you would measure:

Answer 6

serum antibody titer

Question 7

During the lag period between antigen contact and detection of adaptive immunity:

Answer 7

innate immune effectors are eliminating antigen

Question 8

To elicit the best antibodies to mouse MHC I, you should inject it into:

Answer 8

a goat

Question 9

For specific antigen recognition by T cells:

Answer 9

denaturation of antigen does not reduce epitope recognition

Question 10

The immune response to a booster vaccine is called a(n):

Answer 10

secondary response

Question 11

Immunogenicity is not a property of:

Answer 11

haptens

Question 12

Lymphocytes are activated by antigen in the:

Answer 12

lymph nodes

Question 13

A molecule that can be covalently linked to a non-immunogenic antigen to make it an immunogen is called:

Answer 13

a carrier

Question 14

A polyclonal antibody response:

Answer 14

is produced by several B cells recognizing different epitopes on the same antigen

Question 15

Very low doses of antigen may induce:

Answer 15

low zone tolerance

Question 16

A virus vaccine that can activate cytotoxic T cells MUST contain:

Answer 16

live virus

Question 17

These statements are true:

Answer 17

An epitope may be shared by two different antigens.
A protein molecule usually contains multiple epitopes.
Epitopes may be linear or assembled.
Some epitopes are more immunogenic than others.

Question 18

CD antigens:

Answer 18

function as receptors for cytokines and CAMs.

Question 19

A patient desperately needs a bone marrow transplant, and a perfect match cannot be found. The rejection response in unmatched marrow is primarily due to the presence of mature T cells that recognize the recipient’s cells as foreign. To minimize this rejection response, the marrow can be treated before transfusion into the recipient with complement plus antibody to human

Answer 19

CD3

Question 20

Antibody to membrane receptors sometimes inhibits receptor function and sometimes mimics the action of the normal receptor ligand. (For example, some antibodies to insulin receptor block the action of insulin and some mimic the action of insulin.) An antibody which should NOT either block or stimulate B cell function would be anti-

Answer 20

CD56