Antigen Flashcards
The ability of an antigen to induce an immune response does NOT depend on:
ability to enter the thyroid.
BUT DOES depend on: degree og aggregation, dose, size and usual presence in the body
Alum is an effective adjuvant because it:
slows the release of the antigen
Antibody corss-reactivity is demonstrated by antigen binding to:
an antigen that is structurally similar to the immunogen
The antibiotic penicillum is a small molecule that does not induce antibody formation. However, penicillin binds to serum proteins and forms a complex that in some people induces antibody
formation resulting in an allergic reaction. Penicillin is therefore
both an antigen and a hapten
Antigen entering the body in a subcutaneous injection activates its specific lymphocytes in the:
draining lymph nodes
To detect a humoral immune response to influenza virus, you would measure:
serum antibody titer
During the lag period between antigen contact and detection of adaptive immunity:
innate immune effectors are eliminating antigen
To elicit the best antibodies to mouse MHC I, you should inject it into:
a goat
For specific antigen recognition by T cells:
denaturation of antigen does not reduce epitope recognition
The immune response to a booster vaccine is called a(n):
secondary response
Immunogenicity is not a property of:
haptens
Lymphocytes are activated by antigen in the:
lymph nodes
A molecule that can be covalently linked to a non-immunogenic antigen to make it an immunogen is called:
a carrier
A polyclonal antibody response:
is produced by several B cells recognizing different epitopes on the same antigen
Very low doses of antigen may induce:
low zone tolerance
A virus vaccine that can activate cytotoxic T cells MUST contain:
live virus
These statements are true:
An epitope may be shared by two different antigens.
A protein molecule usually contains multiple epitopes.
Epitopes may be linear or assembled.
Some epitopes are more immunogenic than others.
CD antigens:
function as receptors for cytokines and CAMs.
A patient desperately needs a bone marrow transplant, and a perfect match cannot be found. The rejection response in unmatched marrow is primarily due to the presence of mature T cells that recognize the recipient’s cells as foreign. To minimize this rejection response, the marrow can be treated before transfusion into the recipient with complement plus antibody to human
CD3
Antibody to membrane receptors sometimes inhibits receptor function and sometimes mimics the action of the normal receptor ligand. (For example, some antibodies to insulin receptor block the action of insulin and some mimic the action of insulin.) An antibody which should NOT either block or stimulate B cell function would be anti-
CD56
