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Farma 3 > Antifungicos > Flashcards

Antifungicos Flashcards

1
Q

Mecanismo de accion del itraconazol y clotrimazol

A

Inhibicion de la 14 alfa desmetilasa ( esta enzima se codifica por el gen ERG11 ) TIÑAS

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2
Q

Indicaciones para itraconazol

A

Onicomicosis y dermatofitosis, histoplasmosis, candidiasis,,, aspergilosis y blastomicosis

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3
Q

Indicaciones para clotrimazol

A

Dermatofitosis, candidiasis, hitoplasma, dermatofitos

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4
Q

Efectos adversos del itraconazol y clotrimazol

A

Hepatotoxico, prurito y rash cutaneo

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5
Q

Mecanismo de la terbinafina

A

Inhibe la escualeno oxidasa TIÑAS

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6
Q

Mecanismo de griseofulvina

A

Inhibe la formacion y funcion de microtubulos

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7
Q

Indicaciones para terbinafina

A

Onicomicosis

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8
Q

Indicaciones para griseofulvina

A

Dermatofitosis

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9
Q

Efectos adversos de terbinafina

A

Sintomas GI, hepatotoxicidad,

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10
Q

Efectos adversos de griseofulvina

A

Efecto disulfiram, hepatotoxicidad, fotosensibilidad

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11
Q

Mecanismo de accion de anfotericina B

A

Se une a ergosterol y alteran la permeabilidad de la membrana

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12
Q

Indicaciones para anfotericina B

A

Candida, histoplasma, aspergillus, cocci, paracocci

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13
Q

Efectos adversos de anfotericina B

A

Fiebre, escalofrios, taquipnea, hipotension y azotemia, leucoencefalopatia, HIPOKALEMIA, CARDIOMIOTOXICIDAD, NEFROTOXICIDADM, DISMINUCION DE NIVELES DE EPO

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14
Q

Contraindicaciones de anfotericina B

A

Insuficiencia renal

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15
Q

Mecanismo de accion del fluconazol

A

Inhibicion de la 14 alfa desmetilasa

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16
Q

Mecanismo de acción de la nistatina

A

Es un ionoforo, se une a ergosterol, cambia permeabilidad de la membrana celular y permite la salida del contenido

17
Q

Mecanismo de accion de clotrimazol

A

Inhibicion de la 14 alfa desmetilasa

18
Q

Indicaciones para nistatina

A

candidiasis oral y vulvovaginal

19
Q

Indicaciones para fluconazol

A

Candidiasis vulovovaginal, esofagica, urogenital, orofaringea, meningitis criptocococica

20
Q

Indicaciones para clotrimazol

A

Dermatofitosis crusis, pedis, corporis, Candidiasis vulvovaginal

21
Q

Efectos adversos de la nistatina

A

Reaccion de hipersensibilidad, diarrea, dolor abdomina

22
Q

Efectos adversos de fluconazol

A

ALOPECIA, PROLONGACION DEL QT, HEPATOTOXICO, agranulocitosis y rieesgo de convulsiones

23
Q

Efectos adversos del clotrimazol

A

HEPATOTOXICO, PRURITO Y RASH CUTANEO

24
Q

Interacciones del fluconazol

A

CLOPIDOGREL, WARFARINA, RIVAROXABAN, FARMACOS QUE PROLONGUEN EL INTERVALO QT

25
Q

Interacciones del clotrimazol

A

INHIBIDORES DEL CYP3A4, 2D6

Farma 3 (15 decks)

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