Antifungals-DRUGS FOR SYSTEMIC MYCOSES

Question 0

Itraconazole inhibits ________.

Answer 0

cytochrome P450

Question 1

Itraconazole, our prototype for the azole antifungal agents, is active against ___________.

Answer 1

a broad spectrum of fungi.

Question 2

Itraconazole has two major adverse reactions:

Answer 2

cardiosuppression

and liver damage.

Question 3

Itraconazole inhibits CYP3A4, and can thereby raise levels of ______.

Answer 3

many drugs..

Question 4

Drugs that reduce gastric acidity (eg, H2 antagonists, proton pump inhibitors) can greatly reduce absorption of _____.

Answer 4

itraconazole.

Question 5

DRUG INFO
Itraconazole
Itraconazole must not be used with cisapride, quinidine, pimozide, dofetilide, levacetylmethadol, or methadone because very serious (possibly fatal) heart rhythm problems may occur. Also, itraconazole must not be used with felodipine, lovastatin, oral midazolam, nisoldipine, simvastatin, triazolam, or ergot alkaloids (such as dihydroergotamine, ergotamine, ergonovine, methylergonovine) because of a higher chance of serious side effects. If you are currently using any of these medications, tell your doctor or pharmacist before starting itraconazole.
This drug should not be used to treat fungal nail infections if you have a certain heart disease (ventricular dysfunction such as current or history of congestive heart failure-CHF). Itraconazole may infrequently cause or worsen congestive heart failure. Seek immediate medical attention if you develop symptoms of congestive heart failure, such as swelling of the ankles/feet, sudden unexplained weight gain, trouble breathing, or extreme tiredness. Consult your doctor for more details.

Answer 5

Itraconazole is an azole antifungal medication used to treat a variety of fungal infections.
OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.
This drug may also be used to prevent certain fungal infections in patients with HIV.

Question 6

DRUG CARD
Fluconazole
Fluconazole is used to prevent and treat a variety of fungal and yeast infections. It belongs to a class of drugs called azole antifungals. It works by stopping the growth of certain types of fungus.

Answer 6

Products that may interact with this drug include: clopidogrel.
Many drugs besides fluconazole may affect the heart rhythm (QT prolongation), including pimozide, quinidine, macrolide antibiotics (such as erythromycin), among others.
Fluconazole can slow down the removal of other medications from your body, which can affect how they work. An example of the affected drugs is cisapride, among others.