Antifungals

Question 1

Amphotericin (B)

Answer 1

Oral Candidiasis (thrush)
Systemic fungal infections eg. Cryptococcal meningitis

• Gradual general systemic toxicity
• Nephrotoxicity
• Hypokalaemia
• Abnormal LFTs
• Fever, chills, vomiting

Question 2

Nystatin

Answer 2

Oral candidiasis
Used topically-swirled around in mouth. Too toxic for systemic use.

• Oral irritation
• Rash
• Nausea, vomiting, diarrhoea (upon slight ingestion)
• Fatal if swallowed

Question 3

Fluconazole

Sub Class: Azoles

Answer 3

Tinea
Cryptococcal meningitis
Candidiasis

• Nausea, abdominal pain, diarrhoea
• Headache
• Rash
• Rare: hepatitis, Stevens Johnson syndrome