Anti-Dementia

Question 1

Acetyl -Cholinesterase inhibitors

Answer 1

Donepezil
Rivastigmine
Galantamine

Reversible inhibitor of acetyl-cholinesterase, preventing the hydrolysis of ACh, therefore increasing the levels of cortical acetylcholine

• Nausea, vomiting, diarrhoea
• Insomnia
• Syncope, bradicardia, heartblock

Question 2

NMDA Receptor Antagonist

Answer 2

Memantine

Memantine is a non-competitive antagonist for the NMDA receptor, blocking excessive levels of glutamate excitotoxicity that otherwise leads to neural dysfunction.

Constipation
Hypertension
Drowsiness 
Seizures 
Pancreatitis