Antifungals

Question 1

What are the four main classes of antifungals?

Answer 1

Polyenes, Azoles, Allyamines and Echinocandins

Question 2

What are the three most clinically important Azoles?

Answer 2

Fluconazole, Itraconazole and Voriconazole

Question 3

How do Echinocandins act on fungi?

Answer 3

Inhibition of glucan polysaccharide synth.

Question 4

What is Amphotericin B used to treat?

Answer 4

Serious fungal infection (Candida, Aspergillus), yeast and filamentous, IV

Question 5

What fungi is Fluconazole most effective against?

Answer 5

Yeasts e.g. Candida albicans. No function against filamentous fungi

Question 6

What is the spectrum of use for itraconazole?

Answer 6

Filamentous and Yeast fungi - Aspergillus and Dermatophytes

Question 7

Aspergillus could be treated by which Azoles?

Answer 7

Itraconazole and Viroconazole

Question 8

How do Azoles and Allyamines act?

Answer 8

Inhibition of ergesterol synth.

Question 9

What is the mech of Echinocandins?

Answer 9

Inhibition of glucan polysaccharide synth.

Question 10

What is the spectrum of use for Echinocandins?

Answer 10

Serious Candida and Aspergillus infection

Question 11

Name three Echinocandins

Answer 11

Mycafungin, Caspofungin, Anidulafungin

Question 12

Which Azole is resistance developing to by some Yeasts?

Answer 12

Fluconazole

Question 13

What is the class, mech and admin of Nystatin?

Answer 13

Polyene, binds to ergesterol, topical (cream, pessaries, oral suspension)

Question 14

What is Amphotericin B effective against?

Answer 14

Filamentous and Yeast, highly toxic

Question 15

What is Terbinafine?

Answer 15

Allyamine. Used to treat dermatophyte infection of skin and nails

Question 16

Use of Voriconazole?

Answer 16

Treatment of Aspergillosis

Question 17

List all drugs that could be used to treat Aspergillosis

Answer 17

Amphotericin B, Voriconazole, Itraconazole, Echinocandins (Mycafungin, Anidulafungin, Caspofungin)