Antifungals Flashcards
1
Q
Ketoconazole
A
Inhibits ergosterol synthesis
Lacks organism specificity
Used topically
2
Q
Fluconazole
A
More selective that ketoconazole
Good BBB penetration
Preg cat c
3
Q
Itraconazole
A
More selective that ketoconazole
BBW for heart issues
Requires high stomach acidity for absorption
4
Q
Voriconazle
A
Many drug interactions
Hallucinations with high trough levels
Preg cat d
5
Q
Posaconazole
A
Used to prevent candidia and aspergillosis in immunocompromised
6
Q
Terbinafine
A
Lamasil
Topical infection of nails
7
Q
Griseofulvin
A
Topical only
Requires high fat meal for absorption
6-12 mo tx
8
Q
Amphotericin b
A
Disrupts ergosterol membrane
Toxic: renal damage
Broad spectrum
DOC for acute and life threatening fungal infections
