Antifungals

Question 1

Amphotericin B

Answer 1

MOA: Binds ergosterol, creates pore in wall
Use: Severe systemic mycoses
SE: Fever/chills, Hypotension, nephrotoxic, arrhythmias

Question 2

Nystatin

Answer 2

MOA: Binds ergosterol, creates pore in wall
Use: Candida

Question 3

Azoles (fluconazole, itraconazole, clotrimazole)

Answer 3

MOA: Cell wall ergosterol inhibitor
Use: local infection, less severe systemic mycoses, Fluconazole for HIV prophylaxis
SE: Testosterone Synthesis inhibition

Question 4

Flucytosine

Answer 4

MOA: DNA/RNA synthesis inhibitor
Use: Systemic mycoses (meningitis)
SE: Bone marrow suppression

Question 5

Echinocandins (capsofungins, micafungin)

Answer 5

MOA: Inhibit B-Glucan synthesis
Use: Invaseive Aspergillus, Candida

Question 6

Terbinafine

Answer 6

MOA: Inhibits Ergosterol synthesis
Use: Dermatophytes
SE: GI

Question 7

Griseofulvin

Answer 7

MOA: Interferes with microtubules
Use: Dermatophytes, oral infection

Question 8

Antiprotazoans

Answer 8

Pyrimethamine (toxo)

Question 9

Chloroquine

Answer 9

MOA: blocks detox of Heme into hemazoin
Use: Malaria (not falciparum)
For Falciparum (artemether, atovaquone, proguanil) but avoid if G6PD deficient

Question 10

Antihelminthic

Answer 10

Mebendazole, praziquantel (schistosome)