Antifungal Drugs (Echinocandins)

Question 1

MoA of Echinocandins

Answer 1

Echinocandins are cell wall synthesis inhibitors, they inhibit the synthesis of β1,3-d-glucan; leading to cell lysis and death

Question 2

Spectrum of Echinocandins

Answer 2

Broad:
→ Aspergillosis
→ Invasive candidiasis

Question 3

Indications of Caspofungin

Answer 3

1. First-line option for invasive candidiasis and candidemia
2. Second-line option for Aspergillosis in patients who can’t tolerate AmB

Question 4

Indications of Micafungin & Andilufungin

Answer 4

First-line option for invasive candidiasis and candidemia, either treatment or prophylaxis in patients undergoing hematopoietic stem cell transplant (BM transplant)