antifungal drugs

Question 1

What are the indication for Anti-Fungal Meds?

Answer 1

To treat fungal infections, such as athlete’s foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcoal meningitis

Question 2

What are the 3 classes of Antifungals

Answer 2

Polyene, Pyrimidine, and Azole Intravenous

Question 3

What is an example of a drug from Polyene?

Answer 3

Amphotericin B (Generic) and Fungizone (Brand) - Normally given in IV or Oral solution

Question 4

What is an example of Pyrimidine?

Answer 4

Flucytosine (Generic) and Ancoban ( Brand) Oral tablet

Question 5

What is an example of Azole Intravenous?

Answer 5

Fluconazole (generic) and Diflucan (brand) - oral tablet & oral suspension

Question 6

Method of action for Azole?

Answer 6

Interfere with the biosynthesis of ergosterol, which is essential for fungal cell membranes and impairs their growth

Question 7

Method of action for Polyene?

Answer 7

It binds to ergosterol in fungal cell membranes, causing them to become permeable or leaky..

Question 8

Method of action for Pyrimadine/ Flucytosine?

Answer 8

Inhibits the dna and rna synthesis in the pathogen

Question 9

What are the side effects of anti-fungal drugs?

Answer 9

Anaphylaxis, hives, itching, swelling, breathing/ swallowing problems, sudden drop in BP, diarrhea, abdominla pain