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Pharma > Antifungal > Flashcards

Antifungal Flashcards

0
Q

Trichopyton

A

Infect skin nail & hair

Trichopyton rubrum

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1
Q

Epidermophyton

A

Infect skin & nails

Epidermophyton floccosum

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2
Q

Microsporum

A

Affect hair and skin

Classified by habitat

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3
Q

Tinea pedis

A

T. Interdigitale (t.mentagrophytes complex)

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4
Q

Erythrasma

A

Gram positive bacterial infection
- corynebacterium minutissmum

Improve foot hygiene, topical fusion acdinor clindamycin lotion

Will show up pink under woods light

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5
Q

Pure tic slow spreading brown scale and maceration

A

Erythrasma

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6
Q

What is te only type of onychomycosis to affect the dorsal aspect of the nail plate

A

Superficial white onychomycosis

Usually a result of t.mentagrophytes

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7
Q

Cause of proximal white onychomycosis

A

Most commonly caused by trichophyton rubrum

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8
Q

Unicellular round or oval fungal mycosis

A

True yeasts
Malassezia fur fur
Cryptococcus neoformans

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9
Q

Long non-branching stands of fungal infection

A

Candidia spp.

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10
Q

Long branching filaments of fungi that intertwine forming mycelium causing mycosis

A

Moulds

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11
Q

Trichophyton is classified as a

A

Dermatophyte

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12
Q

Dermatophytes digest

A

Keratin in hair, skin & nails

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13
Q

Amorolfine is the active ingredient in

A

Loceryl 5% paint

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14
Q

Nystatin (topical)

A

Mycostatin

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15
Q

Terbinafine is the active ingredient in

A

Lamisil 1%

Lamisil tablets in specific circumstances

16
Q

Griseofulvin is the active ingredient in

A

Grisovin

Oral in specified circumstances

17
Q

Broad spectrum antifungals

A

Azoles

18
Q

Narrow spectrum of antifungal

A

Griseofulvin

19
Q

Cell wall synthesis inhibiting antifungals

A

Azoles
Allylamines
Amorolfine
Echinocandins

20
Q

Predominant component of fungal cell wall

A

Ergosterol

21
Q

Antifungals that interfere with cell wall function

A

Amphotericin

Nystatin

22
Q

DNA synthesis inhibiting antifungals

A

Pyrimides - flucytosine

Benzofurines - griseofulvin

23
Q

Miconazole is available as a tincture for use on nails what drug class is it and what is the MOA & brand names

A

Daktarin, Resolve
Azoles - imidazoles
Inhibit enzyme, impairing synthesis of ergosterol in cell wall

24
Q

Imidazoles

A

All administered topically for 2-4 weeks

  • Miconazole
  • clotrimozole
  • econazole
  • bifonazole
  • ketoconazole
25
Q

Triazoles

A

All given orally

  • Fluconazole
  • Itraconazole
  • Voriconazole
  • Posaconazole (v serious cases)
26
Q

Canestan oral once-daily, mycospor

A

Bifonazole (cream1%)

Azoles - imidazole

Inhibit cell wall synthesis

27
Q

Canesten, clonea

A

Clotrimozole (cream & lotion 1%)

Azoles - imidazole

Inhibit cell wall synthesis

28
Q

Pevaryl

A

Econazole (cream 1%)

Azoles - imidazole

Inhibit cell wall synthesis

29
Q

Nizoral cream

Daktagold

A

Ketoconazole (cream 1%)

Azoles - imidazole

Inhibit cell wall synthesis

30
Q

Fluconazole interacts with

A

Warfarin - increase INR
Anti- arrhytmics (amidarone) increase QT interval
Macrolides

31
Q

What Azoles would you use in a severe systemic fungal infection

A

Voriconazole

Posaconazole

32
Q

In pregnancy the safe Azoles are

A

Clotrimozole
Miconazole
And econazole

33
Q

Allylamines

A

Terbinafine - Lamisil
Inhibit an enzyme (squalene epoxidase) preventing ergosterol synthesis

Fungicidal against dermatophytes
Fungistatic against Candida albicans

34
Q

Terbinafine interactions

A

Venlafaxine
Triglyclic antidepressants
Rifampicin

35
Q

Do not use Lamisil for

A

Longer than 4weeks

Moccasin/plantar type tinea pedis

36
Q

Loceryl

A

Amorolfine targets 2 enzyme points in synthesis of ergosterol which compromises cell wall

Broad coverage for dermatophytes and candida spp (high affinity for keratin)

37
Q

Bifonazole

A

Urea ointment - softens nail

Bifonazole cream

Pharma (6 decks)

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