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40 Quinolones, antifolates, other > Antifolate drugs > Flashcards

Antifolate drugs Flashcards

1
Q

Groups of antifolate drugs

A

Sulfonamides

Folate reductase inhibitors

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2
Q

Sulfonamides - MOA

A

Inhibits synthesis of dihydrofolate in some bacteria and parasites

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3
Q

Folate reductase inhibitors - MOA

A

Inhibit dihydrofolate reductase

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4
Q

Folate reductase inhibitors (3 drugs)

A

Methotrexate
Trimethoprim
Pyrimethamine

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5
Q

Pyrimethamine - Indications (briefly)

A

Toxoplasmosis

Malaria

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6
Q

Methotrexate - Indications (briefly)

A

Neoplasm

Autoimmune diseases

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7
Q

Sulfonamides - advice to pt

A

Drink lots of water (prevent crystalluria)

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8
Q

Sulfonamides - adverse effects

A

Crystalluria, erythema multiforme, Stevens-Johnson syndrome, hepatitis, hematopoietic toxicity.
G6PD deficiency: Hemolytic anemia

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9
Q

Sulfonamides - indications

A

UTIs

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10
Q

Silver sulfadiazine - Indications

A

Burn infections

Superficial skin infections

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11
Q

Sulfacetamide - indications

A

Blepharitis, conjunctivits (topical)

Ocular infections, trachoma

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12
Q

Trimethoprim - distribution in body

A

Concentrated in prostate tissues & vaginal fluids

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13
Q

Trimethoprim - indications

A

Bacterial prostatitis and vaginitis

UTI (often as TMP-SMX)

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14
Q

Trimethoprim - adverse effects

A

Hepatitis, thrombocytopenia, leukopenia

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15
Q

Which drug is often combined with trimethoprim and why?

A

Sulfamethoxazole. They have synergistic activity.

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16
Q

Trimethoprim-Sulfamethoxazole - Indications

A

Pulmonary infections (by P. jiroveci + Nocardia asteroides)

17
Q

Trimethoprim-Sulfmethoxazole - adverse effects

A

Megaloblastic anemia

40 Quinolones, antifolates, other (4 decks)

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