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FARMACOLOGÍA > ANTIEMÉTICO > Flashcards

ANTIEMÉTICO Flashcards

1
Q

Metoclopramida: mecanismo de acción

A
  • Antagonista de receptores D2 y 5Ht3
  • Acelera el vaciado gástrico
  • Mejor la motilidad intestinal (Procinético)
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2
Q

Metoclopramida: Indicado en…

A
  • Antinauseosos
  • Antimemetico
  • Gastroparesia diabética
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3
Q

Metoclopramida: farmacocinética IV

A

1-3 min de inicio de acción

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4
Q

Metoclopramida: farmacocinética IM

A

10-15 min de inicio de acción

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5
Q

Metoclopramida: farmacocinética VO

A

30-60 min inicio de acción

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6
Q

Metoclopramida: efectos adversos

A
  • Efectos extrpiramidales (+10%, solo en uso crónico)
  • Cansancio
  • Sedación
  • Inquietud
  • Hiperprolactemia (galacotrrea y ginecomastia)
  • Síndorme neuroléptico maligno
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7
Q

Antagonistas de los receptores serotoninérgicos 5HT3: mecanismo de acción

A

Antagonistas selectivo de 5HT3

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8
Q

Antagonistas de los receptores serotoninérgicos 5HT3: fármacos

A

Ondansertón y palonestrón (más caro)

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9
Q

Antagonistas de los receptores serotoninérgicos 5HT3: farmacocinética

A
  • alimentos + absorción
  • metabolizado por CYP3A4, 2D6 y 1A2
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10
Q

Vía de administración de Ondasetrón

A

VO y IV
VIda media 6 horas

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11
Q

Vía de administración de palonosertón

A

IV: para quimioterapia
Vida media de 40 horas

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12
Q

Antagonistas de los receptores serotoninérgicos 5HT3: Efectos adversos

A
  • Bien tolerados
  • cefalea
  • estreñimiento
  • diarrea
    riesgo de sx serotoninérgico
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13
Q

Antagonista de receptores de neurocinina I: Fármacos

A

Aprepitant

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14
Q

Antagonista de receptores de neurocinina I: mecanismo de acción

A

antagonista de receptores NK1

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15
Q

Antagonista de receptores de neurocinina I: farmacocinética

A
  • sustrato e inhibidor de CYP3A4
  • inductor de CYP2C9
  • tiene una forma específica de tomarse
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16
Q

Antagonista de receptores de neurocinina I: indicado en…

A
  • Prevencin y tx en. quimioterapia, radioterapia y posoperatorio
17
Q

Antagonista de receptores de neurocinina I: efectos adversos

A

inespecíficos y reacciones alérgicas

FARMACOLOGÍA (6 decks)

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