Antidysrythmic, Positive Inotropic, Adrenergic drugs (Week 4) Flashcards
What is the Vaughan Williams classification of Antidysrhythmic drugs?
This system is based on the electrophysiological effect of particular drugs on the action potential. This approach identifies 4 major classes of drugs: Class I (a, b, c) , II, III, and IV.
What do Adrenergic Drugs mimic?
The effects of the SNS neurotransmitters norepinephrine, epinephrine, and dopamine (collectively referred to as catecholamines).
Contraindications for adrenergic drugs
The only usual contraindications to the use of adrenergic drugs are known drug allergy and severe hypertension.
Adverse effects for adrenergic drugs?
headache restlessness tremors nervousness dizziness insomnia euphoria chest pain hypertension tachycardia dry mouth nausea vomiting
Mechanism of Action for adrenergic drugs?
Adrenergic drugs stimulate adrenergic receptor sites located on the smooth muscles, vasoconstriction occurs.
Indications for adrenergic drugs?
Used to treat a wide variety of illnesses and conditions. Their selectivity for either a- or b- adrenergic receptors and their affinity for certain tissues or organs determine the setting in which they are most commonly used.
Interactions with adrenergic drugs?
Numerous interactions can occur usually resulting in a diminished adrenergic affect. Others include: DIGOXIN, anaesthetic drugs, Tricyclic antidepressants, MOAIs, antihistamines, and thyroid preparations.
Nursing Assessment for adrenergic drugs?
1) medication history and allergies
2) respiratory
3) kidneys and liver
Mechanism of action for Antidysrhythmic drugs?
They work by correcting abnormal cardiac electrophysiological function.
Class 1a of Antidysrhythmic drugs?
(Quinidine, procainamide, and disopyramide) block sodium channels; more specifically, they delay repolarization and increase the APD.
Class 1b of Antidysrhythmic drugs?
(Phenytoin sodium and lidocaine) also block sodium channels but unlike Class 1a drugs, they accelerate repolarization and decrease the APD.
Class 1c of Antidysrhythmic drugs?
(Flecainide and propafenone) have more pronounced effect on the blockade sodium channels but have little effect on repolarization or the APD.
Class 2 Antidysrhythmic drugs?
Are the b- adrenergic blockers and they are used for antihypertensives and antianginal drugs. They work by blocking sympathetic nervous system stimulation to the heart.
Class 3 Antidysrhythmic drugs?
(Amiodarone, dronedarone, sotalol, and ibutilide) increase the APD by prolonging repolarization in phase 3. The primary role of potassium channels in cardiac action potentials is cell repolarization; these drugs are also refered to as calcium-channel blockers.
Class 4 Antidysrhythmic drugs?
(Verapamil, diltiazem) are the calcium-channel blockers, which, similar to b-blockers, are also used as antianginal drugs and antihypertensives.
