Antidotes Flashcards
Antidote for salicylates
NaHCO3 (alkalinize urine); dialysis
Antidote for acetaminophen
N-acetylcysteine - replenishes glutathione
Antidote for amphetamines
NH4Cl (acidify urine)
AChE inhibitors, organophosphates
Atropine; pralidoxime
Antidote for antimuscarinic/anticholinergic agents
Physostigmine salicylate; control hypothermia
Antidote for B-blockers
Glucagon
Antidote for digitalis
Normalize K+ (digitalis –> hyperkalemia); lidocaine; anti-digitalis Fab fragments; Mg2+
Antidote for iron
Deferoxamine; deferasirox
Antidote for lead
CaEDTA; dimercaprol; succimer; penicillamine
Antidote for mercury
Dimercaprol (BAL); succimer
Antidote for arsenic
Dimercaprol (BAL); succimer; penicillamine
Antidote for gold
Dimercaprol (BAL); succimer; penicillamine
Antidote for copper
Penicillamine
*Wilson’s disease
Antidote for cyanide
Nitrite + thiosulfate; hydroxocobalamin
Antidote for methemoglobin
Methylene blue; vitamin C
Antidote for carbon monoxide
100% O2; hyperbaric O2
Antidote for methanol or ethylene glycol (antifreeze)
Fomepizole > ethanol; dialysis
Antidote for opioids
Naloxone/naltrexone
Antidote for benzodiazepines
Flumazenil
Antidote for TCAs
NaHCO3 (plasma alkalinization)
Antidote for heparin
Protamine
Antidote for warfarin
Vitamin K; fresh frozen plasma
Antidote for tPA, streptokinase and urokinase
Aminocaproic acid
Antidote for theophylline
B-blocker
What can dimercaprol be used as an antidote for?
Lead, mercury, arsenic and gold
What can succimer be used as an antidote for?
Lead, mercury, arsenic and gold
*same as dimercaprol
What can penicillamine be used as an antidote for?
Lead, copper, arsenic and gold
