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Pharmacology > antidepressents > Flashcards

antidepressents Flashcards

1
Q

SSRIs: Fluoxetine MOA

A

blocks reuptake of serotonin
produces CNS excitation

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2
Q

SSRIs: Fluoxetine indications

A

major depression
bipolar disorder
panic disorder
OCD

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3
Q

SSRIs: Fluoxetine AE

A

weight gain
nausea
suicidal thoughts
sexual dysfunction
serotonin syndrome begins within 2-72hrs

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4
Q

SSRIs: Fluoxetine nursing considerations

A
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5
Q

SSRIs: Venlafaxine MOA

A

blocks reuptake of serotonin and norepi

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6
Q

SSRIs: Venlafaxine indications

A

GAD,
major depression,
social anxiety,
panic disorder

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7
Q

SSRIs: Venlafaxine AE

A

N/V
headache
HTN
nervousness
anorexia

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8
Q

SSRIs: Venlafaxine nursing considerations

A

taper over 2 weeks to avoid withdrawal
serotonin syndrome

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9
Q

Tricyclic ANtidepressant Imipramine (Tofranil) MOA

A

block reuptake of serotonin and norepi
prolong 1/2 life

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10
Q

Tricyclic ANtidepressant Imipramine (Tofranil) indications

A

depression
bipolar
fibromyalgia syndrome

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11
Q

Tricyclic ANtidepressant Imipramine (Tofranil) AE

A

sedation
orthostatic hypotension
anticholinergic effects: dry mouth, blurred vision, urinary retention, constipation, tachycardia, photophobia
! cardiac toxicity, sudden death!

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12
Q

Tricyclic ANtidepressant Imipramine (Tofranil) nursing considerations

A

lethal dose= 8x average therapuetic dose
treatment= gastric lavage, activated charcoal
give suicidal pt 1 week supply= minimize od

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13
Q

Monoamine Oxidase Inhibitors: Phenelzine MOA

A

block monoamine oxidase
increase norepi, dopamine, serotonin, and tyramine

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14
Q

Monoamine Oxidase Inhibitors: Phenelzine indications

A

depression
bulimia
nervosa
panic disorder
PTSD
OCD

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15
Q

Monoamine Oxidase Inhibitors: Phenelzine AE

A

orthostatic hypotension
many durg interactions

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16
Q

Monoamine Oxidase Inhibitors: Phenelzine nursing considerations

A

hypertensive crisis when tyramine rich food consumed

17
Q

Atypical antidepressants: Bupropion MOA

A

blocks dopamine and/or norepi reuptake
effects seen in 1-3 weeks

18
Q

Atypical antidepressants: Bupropion indications

A

major depression
prevention of SAD
unlabeled ADHD

19
Q

Atypical antidepressants: Bupropion AE

A

agitation
headache
dry mouth
constipation
weight loss
GI upset
dizziness
tremor
insomnia
blurred vision
tachycardia
!seizure!

20
Q

Atypical antidepressants: Bupropion nursing considerations

A

no sexual dysfunction

21
Q

Anxiolytics: Alprazolam (Xanax) MOA

A

increased inhibitory effects of GABA

22
Q

Anxiolytics: Alprazolam (Xanax) indications

A

GAD, panic disorder

23
Q

Anxiolytics: Alprazolam (Xanax) AE

A

sedation
lightheadedness
ataxia
decreased cognitive function
increased CNS depression with other CBS depressants
retrograde amnesia

24
Q

Anxiolytics: Alprazolam (Xanax) nursing considerations

A

short-term use can lead to dependence
contraindicated with OSA

Pharmacology (10 decks)

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