antidepressents Flashcards
SSRIs: Fluoxetine MOA
blocks reuptake of serotonin
produces CNS excitation
SSRIs: Fluoxetine indications
major depression
bipolar disorder
panic disorder
OCD
SSRIs: Fluoxetine AE
weight gain
nausea
suicidal thoughts
sexual dysfunction
serotonin syndrome begins within 2-72hrs
SSRIs: Fluoxetine nursing considerations
SSRIs: Venlafaxine MOA
blocks reuptake of serotonin and norepi
SSRIs: Venlafaxine indications
GAD,
major depression,
social anxiety,
panic disorder
SSRIs: Venlafaxine AE
N/V
headache
HTN
nervousness
anorexia
SSRIs: Venlafaxine nursing considerations
taper over 2 weeks to avoid withdrawal
serotonin syndrome
Tricyclic ANtidepressant Imipramine (Tofranil) MOA
block reuptake of serotonin and norepi
prolong 1/2 life
Tricyclic ANtidepressant Imipramine (Tofranil) indications
depression
bipolar
fibromyalgia syndrome
Tricyclic ANtidepressant Imipramine (Tofranil) AE
sedation
orthostatic hypotension
anticholinergic effects: dry mouth, blurred vision, urinary retention, constipation, tachycardia, photophobia
! cardiac toxicity, sudden death!
Tricyclic ANtidepressant Imipramine (Tofranil) nursing considerations
lethal dose= 8x average therapuetic dose
treatment= gastric lavage, activated charcoal
give suicidal pt 1 week supply= minimize od
Monoamine Oxidase Inhibitors: Phenelzine MOA
block monoamine oxidase
increase norepi, dopamine, serotonin, and tyramine
Monoamine Oxidase Inhibitors: Phenelzine indications
depression
bulimia
nervosa
panic disorder
PTSD
OCD
Monoamine Oxidase Inhibitors: Phenelzine AE
orthostatic hypotension
many durg interactions