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NAPLEX: Psychiatric Disorders > Antidepressants: Drugs > Flashcards

Antidepressants: Drugs Flashcards

1
Q

Citalopram

“Group 1”

A

Brand: Celexa
Dosage: 10-60mg/day
Class: SSRI
SEs: Lightheadedness, snycope, sweating, diarrhea, nausea, xerostomia, confusion, dizziness, somnolence, tremor, hallucinations, ejaculation disorders, impotence, female sexual disorder, rhinitis, fatigue
Monitoring: Symptoms, bleeding, suicidal tendencies, withdrawl
Drug Interactions: MAOIs, SSRIs, triptans, linezolid, CYP3A inducers, tramadol
Other: R/S Racemic mixture

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2
Q

Escitalopram

“Group 1”

A

Brand: Lexapro
Dosage: 10-20mg/day
Class: SSRI
SEs: Lightheadedness, snycope, sweating, diarrhea, nausea, xerostomia, confusion, dizziness, somnolence, tremor, hallucinations, ejaculation disorders, impotence, female sexual disorder, rhinitis, fatigue
Monitoring: Symptoms, bleeding, suicidal tendencies, withdrawl
Drug Interactions:
Other: Pure S isoform (vs. R/S racemic mixture)

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3
Q

Fluoxetine

“Group 1”

A

Brand: Prozac, Sarafem, Rapiflux
Dosage: 20-60mg/day or 80mg QW
Class: SSRI
SEs: Lightheadedness, snycope, sweating, diarrhea, nausea, xerostomia, confusion, dizziness, somnolence, tremor, hallucinations, ejaculation disorders, impotence, female sexual disorder, rhinitis, fatigue
Monitoring: Symptoms, bleeding, suicidal tendencies, withdrawl
Drug Interactions: Serotonergic meds, st. john’s wort, phenytoin, linezolid, CYP450s
Other: 5wk washout of prior MAOI, NO TAPER REQUIRED

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4
Q

Fluvoxamine

“Group 1”

A

Brand: Luvox
Dosage: 50-300mg/day
Class: SSRI
SEs: Lightheadedness, snycope, sweating, diarrhea, nausea, xerostomia, confusion, dizziness, somnolence, tremor, hallucinations, ejaculation disorders, impotence, female sexual disorder, rhinitis, fatigue
Monitoring:
Drug Interactions: Serotonergic meds, st. john’s wort, phenytoin, linezolid, CYP450s

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5
Q

Paroxetine

“Group 1”

A

Brand: Paxil
Dosage: 20-60mg/day
Class: SSRI
SEs: Lightheadedness, snycope, sweating, diarrhea, nausea, xerostomia, confusion, dizziness, somnolence, tremor, hallucinations, ejaculation disorders, impotence, female sexual disorder, rhinitis, fatigue
Monitoring:
Drug Interactions: Serotonergic meds, st. john’s wort, tramadol
Other: None

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6
Q

Sertraline

“Group 1”

A

Brand: Zoloft
Dosage: 50-200mg/day
Class: SSRI
SEs: Lightheadedness, snycope, sweating, diarrhea, nausea, xerostomia, confusion, dizziness, somnolence, tremor, hallucinations, ejaculation disorders, impotence, female sexual disorder, rhinitis, fatigue
Monitoring:
Drug Interactions: Serotoneric meds, st. john’s wort, tramadol
Other: Oral concentrate contains alcohol

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7
Q

Vortioxetine

“Group 2”

A 
Brand: Brintellix
Dosage: 5-20mg/day
Class: SSRI
SEs: None
Monitoring: None
Drug Interactions: CYP3A4 + 2D6 substrates, 3A4 inducers, MAOIs, SSRIs, triptans, linezolid, tramadol
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8
Q

Vilazodone

“Group 3”

A

Brand: Viibryd
Dosage: 10-40mg/day
Class: SSRI + partial 5HT1A receptor agonist*
SEs: Diarrhea, nausea, xerostomia, dizziness, insomnia
Monitoring: Reduction/resolution symptoms, suicidal
Drug Interactions: other serotonergic meds, WARFARIN, NSAIDs, ANTIPLATELETS
Other: Take with food, avoid abrupt discontinuation, unique risk of bleeding

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9
Q

Amitriptyline

A

Brand: Elavil, Vanatrip
Dosage: 50-300mg/day (QD-TID)
Class: TCA
CIs: MAOIs, post-MI (acute recovery), hypersensitivity
SEs: Anticholinergic symptoms, weight gain, bloating, blurred vision, xerostomia, constipation, asthenia, dizziness, somnolence, headache, fatigue
Monitoring: Symptom reduction, abrupt withdrawl, worsening of depression, BP, EKG
Drug Interactions: MAOIs, SSRIs, triptans, linezolid, st. john’s wort, tramadol
Other: Avoid with high suicide risk, overdose dangerous, dispense small quantities

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10
Q

Amoxapine

A

Brand: Ascendin
Dosage: 50-600mg/day (BID-TID)
Class: TCA
CIs: MAOIs, post-MI (acute recovery), hypersensitivity
SEs: Anticholinergic symptoms, weight gain, bloating, blurred vision, xerostomia, constipation, asthenia, dizziness, somnolence, headache, fatigue
Monitoring: Symptom reduction, abrupt withdrawl, worsening of depression, BP, EKG
Drug Interactions: MAOIs, SSRIs, triptans, linezolid, st. john’s wort, tramadol
Other: Avoid with high suicide risk, overdose dangerous, dispense small quantities

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11
Q

Clomipramine

A

Brand: Anafranil
Dosage: 75-250mg/day (divided TID)
Class: TCA
CIs: MAOIs, post-MI (acute recovery), hypersensitivity
SEs: Anticholinergic symptoms, weight gain, bloating, blurred vision, xerostomia, constipation, asthenia, dizziness, somnolence, headache, fatigue
Monitoring: Symptom reduction, abrupt withdrawl, worsening of depression, BP, EKG
Drug Interactions: MAOIs, SSRIs, triptans, linezolid, st. john’s wort, tramadol
Other: Avoid with high suicide risk, overdose dangerous, dispense small quantities

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12
Q

Desipramine

A

Brand: Norpramin
Dosage: 100-300mg/day (QD-divided doses)
Class: TCA
CIs: MAOIs, post-MI (acute recovery), hypersensitivity
SEs: Anticholinergic symptoms, weight gain, bloating, blurred vision, xerostomia, constipation, asthenia, dizziness, somnolence, headache, fatigue
Monitoring: Symptom reduction, abrupt withdrawl, worsening of depression, BP, EKG
Drug Interactions: MAOIs, SSRIs, triptans, linezolid, st. john’s wort, tramadol
Other: Avoid with high suicide risk, overdose dangerous, dispense small quantities

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13
Q

Doxepin

A

Brand: Sinequan, Prudoxin, Zonalon
Dosage: 25-300mg/day (QD-TID)
Class: TCA
CIs: MAOIs, post-MI (acute recovery), hypersensitivity
SEs: Anticholinergic symptoms, weight gain, bloating, blurred vision, xerostomia, constipation, asthenia, dizziness, somnolence, headache, fatigue
Monitoring: Symptom reduction, abrupt withdrawl, worsening of depression, BP, EKG
Drug Interactions: MAOIs, SSRIs, triptans, linezolid, st. john’s wort, tramadol
Other: Avoid with high suicide risk, overdose dangerous, dispense small quantities

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14
Q

Imipramine

A

Brand: Tofranil
Dosage: 100-300mg/day (QD-divided)
Class: TCA
CIs: MAOIs, post-MI (acute recovery), hypersensitivity
SEs: Anticholinergic symptoms, weight gain, bloating, blurred vision, xerostomia, constipation, asthenia, dizziness, somnolence, headache, fatigue
Monitoring: Symptom reduction, abrupt withdrawl, worsening of depression, BP, EKG
Drug Interactions: MAOIs, SSRIs, triptans, linezolid, st. john’s wort, tramadol
Other: Avoid with high suicide risk, overdose dangerous, dispense small quantities

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15
Q

Nortriptyline

A

Brand: Pamelor, Aventyl
Dosage: 25mg (TID-QID divided)
Class: TCA
CIs: MAOIs, post-MI (acute recovery), hypersensitivity
SEs: Anticholinergic symptoms, weight gain, bloating, blurred vision, xerostomia, constipation, asthenia, dizziness, somnolence, headache, fatigue
Monitoring: Symptom reduction, abrupt withdrawl, worsening of depression, BP, EKG
Drug Interactions: MAOIs, SSRIs, triptans, linezolid, st. john’s wort, tramadol
Other: Avoid with high suicide risk, overdose dangerous, dispense small quantities

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16
Q

Protriptyline

A

Brand: Vivactil
Dosage: 15-60mg/daily (TID-QID divided)
Class: TCA
CIs: MAOIs, post-MI (acute recovery), hypersensitivity
SEs: Anticholinergic symptoms, weight gain, bloating, blurred vision, xerostomia, constipation, asthenia, dizziness, somnolence, headache, fatigue
Monitoring: Symptom reduction, abrupt withdrawl, worsening of depression, BP, EKG
Drug Interactions: MAOIs, SSRIs, triptans, linezolid, st. john’s wort, tramadol
Other: Avoid with high suicide risk, overdose dangerous, dispense small quantities

17
Q

Trimipramine

A

Brand: Surmontil
Dosage: 75-300mg daily (QD-TID)
Class: TCA
CIs: MAOIs, post-MI (acute recovery), hypersensitivity
SEs: Anticholinergic symptoms, weight gain, bloating, blurred vision, xerostomia, constipation, asthenia, dizziness, somnolence, headache, fatigue
Monitoring: Symptom reduction, abrupt withdrawl, worsening of depression, BP, EKG
Drug Interactions: MAOIs, SSRIs, triptans, linezolid, st. john’s wort, tramadol
Other: Avoid with high suicide risk, overdose dangerous, dispense small quantities

18
Q

Duloxetine

A

Brand: Cymbalta
Dosage: 30-120mg QD
Class: SNRI
CIs: MAOIs, hypersensitivity, uncontrolled narrow angle glaucoma
SEs: Palpitations, diaphroesis, constipation, decreased appetite, D/N, xerostomia, asthenia, dizziness, insomnia, somnloence, vertigo, blurred vision, polyuria, reduced libido, cough, nasopharyngitis, fatigue
Monitoring: S/Sx, withdrawl, worsening depression
Drug Interactions: MAOIs, SSRIs, triptans, linezolid, st. john’s wort, tramadol
Other: >60mg doses not efficacious

19
Q

Venlafaxine

A

Brand: Effexor (XR)
Dosage: 32.5-375mg/day (QD-TID)
Class: SNRI
CIs: MAOIs, hypersensitivity
SEs: HTN, sweating, weight loss, constipation, loss of appetite, nausea, xerostomia, insomnia/somnolence, ED
Monitoring:
Drug Interactions: MAOIs, SSRIs, triptans, linezolid, st. john’s wort, tramadol

20
Q

Levomilnacipran

A

Brand: Fetzima
Dosage: 20-120mg/day
CIs: MAOIs (within 21 days), linezolid, hypersensitivity, methylene blue, uncontrolled narrow angle glaucoma
Class: SNRI
Drug Interactions: CYP3A4, MAOIs, SSRIs, triptans, linezolid, st john’s wort, tramadol, anticoagulants + thrombolytics
Other: Renal dose adjustment

21
Q

Desvenlafaxine

A

Brand: Pristiq (ER = Khedezla)
Dosage: 50-400mg/day
Class: SNRI
CIs: Hypersensitivity
SEs: Orthostatic hypotension (elderly), nausea, dizziness, insomnia, hyperhidrosis, constipation, somnolence, decreased appetite, anxiety, male sexual dysfunction
Monitoring: Renal Fx, therapy response, BP, depression/suicidality
Drug Interactions: MAOIs, serotonergic agents, bleeding risk with anticoagulants + thrombolytics
Other: Renal dose adjustment required, no abrupt discontinuation

22
Q

Nefazodone

A

Brand: Serzone
Dosage: 200-600mg/day (BID)
Class: SNRI
CIs: Previous associated hepatic damage, hypersensitivity, astemizole, carbamazepine, cisapride, triazolam, terfenadine, pimozide
SEs: LIghtheadedness, constipation, indigestion, nausea, xerostomia, asthenia, confusion, dizziness, headache, insomnia, memory impairment, somnolence
Monitoring: S/Sx, withdrawl, depression S/Sx

23
Q

Isocarboxazid

A

Brand: Marplan
Dosage: 20-60mg/day (BID-QID)
Class: MAOI
CIs: CV disorders, HTN, cerebrovascular disorder, interacting meds, general anesthesia, headache, hypersensitivity, pheochromocytoma, renal fx impairment
SEs: Weight gain, constipation, xerostomia, dizziness, headache, insomnia, somnolence, blurred vision, anxiety, mania
Monitoring: S/Sx depression, BP, liver fx
Drug Interactions: Serotonergic drugs, CYP3A4 interactions, antihistamine/sedative/anesthetic substances, bupropion, buspirone, narcotics, barbiturate, ethanol, dextromethorphan, excessive caffeine, foods with high tyramine, meperidine, SSRis, sympathomimetic drugs, MAOIs, TCAs, maprotiline, carbamazepine, cyclobenzaprine
Other: Infrequent use due to SEs

24
Q

Phenelzine

A

Brand: Nardil
Dosage: 45-90mg/day (TID-QID)
Class: MAOI
CIs: CV disorders, HTN, cerebrovascular disorder, interacting meds, general anesthesia, headache, hypersensitivity, pheochromocytoma, renal fx impairment
SEs: Weight gain, constipation, xerostomia, dizziness, headache, insomnia, somnolence, blurred vision, anxiety, mania
Monitoring: S/Sx depression, BP, liver fx
Drug Interactions: Serotonergic drugs, CYP3A4 interactions, antihistamine/sedative/anesthetic substances, bupropion, buspirone, narcotics, barbiturate, ethanol, dextromethorphan, excessive caffeine, foods with high tyramine, meperidine, SSRis, sympathomimetic drugs, MAOIs, TCAs, maprotiline, carbamazepine, cyclobenzaprine
Other: Infrequent use due to SEs

25
Q

Tranylcypromine

A

Brand: Parnate
Dosage: 30-60mg/day (divided doses)
Class: MAOI
CIs: CV disorders, HTN, cerebrovascular disorder, interacting meds, general anesthesia, headache, hypersensitivity, pheochromocytoma, renal fx impairment
SEs: Weight gain, constipation, xerostomia, dizziness, headache, insomnia, somnolence, blurred vision, anxiety, mania
Monitoring: S/Sx depression, BP, liver fx
Drug Interactions: Serotonergic drugs, CYP3A4 interactions, antihistamine/sedative/anesthetic substances, bupropion, buspirone, narcotics, barbiturate, ethanol, dextromethorphan, excessive caffeine, foods with high tyramine, meperidine, SSRis, sympathomimetic drugs, MAOIs, TCAs, maprotiline, carbamazepine, cyclobenzaprine
Other: Infrequent use due to SEs

26
Q

Selegiline

A

Brand: Emsam
Dosage: 6mg QD (TRANSDERMAL PATCH)
Class: MAOI
CIs: CV disorders, HTN, cerebrovascular disorder, interacting meds, general anesthesia, headache, hypersensitivity, pheochromocytoma, renal fx impairment
SEs: none
Monitoring: none
Drug Interactions: Serotonergic drugs, CYP3A4 interactions, antihistamine/sedative/anesthetic substances, bupropion, buspirone, narcotics, barbiturate, ethanol, dextromethorphan, excessive caffeine, foods with high tyramine, meperidine, SSRis, sympathomimetic drugs, MAOIs, TCAs, maprotiline, carbamazepine, cyclobenzaprine
Other: PARKINSON’S mainly (less common for depression)

27
Q

Bupropion

A

Brand: Wellbutrin, Zyban
Dosage: 100-450mg/day (QD-QID)
Class: Aminoketone + weak dopamine and norepi reuptake inhibitor
CIs: MAOIs, bulimia/anorexia, alcohol withdrawl, seizure disorder
SEs: Taste changes, agitation, seizure
Monitoring: S/Sx reduction, abrupt discontinuation, suicide, seizure
Drug Interactions: MAOIs
Other: Smoking cessation, mostly dopamine reuptake activity

28
Q

Maprotiline

A

Brand: Ludiomil
Dosage: 75-225mg/day (BID-TID)
Class: Tetracyclic antidepressant
CIs: MAOIs, hypersensitivity, seizure, acute post-MI
SEs: Hypotension, tachycardia, rash, weight gain, constipation, N/V, pancreatitis, xerostomia/reduced saliva
Monitoring: Withdrawl, S/Sx, suicide
Drug Interactions: None

29
Q

Mirtazapine

A

Brand: Remeron, Solutab
Dosage: 15-45mg/day (qHS)
Class: Tetracyclic antidepressants
CIs: MAOIs, hypersensitivity, seizure, acute post-MI
SEs: Increased appetite, hyperlipidemia, weight gain, constipation, elevated transaminases
Monitoring: Withdrawl, S/Sx, suicide
Drug Interactions: MAOI, clonidine, tramadol, fluoxetine, fluvoxamine, linezolid, olanzapine, venlafaxine
Other: HS dosing, appetite stimulant (off-label)

NAPLEX: Psychiatric Disorders (7 decks)

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