Antidepressants: Class + Guidelines

Question 1

SSRIs (“Group 1-3”)

[CEFFPSVV]

Answer 1

Citalopram (Celexa)
Escitalopram (Lexapro)
Fluoxetine (Prozac/Sarafem/Rapiflux)
Fluvoxamine (Luvox)
Paroxetine (Paxil)
Sertraline (Zoloft)
Vortioxetine (Brintellix)
Vilazodone (Viibryd)

Question 2

Side Effects: SSRIs (“Group 1”) [16]

[Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline]

Answer 2

[Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline]

1. ) Lightheadedness**
2. ) Syncope (BP drop ==> loss of consciousness)**
3. ) Sweating**
4. ) Diarrhea
5. ) Nausea
6. ) Xerostomia (dry mouth)
7. ) Confusion**
8. ) Dizziness
9. ) Somnolence**
10. ) Tremor**
11. ) Hallucinations**
12. ) Ejaculation Disorder**
13. ) Impotence**
14. ) Rhinitis**
15. ) Fatigue**
16. ) Female Sexual Disorder**

Question 3

Side Effects: SSRIs (“Group 2”)

[Vortioxetine]

Answer 3

[Vortioxetine]

None

Question 4

Side Effects: SSRIs (“Group 3”) [5]

[Vilazodone]

Answer 4

[Vilazodone]

1. ) Diarrhea
2. ) Nausea
3. ) Xerostomia (dry mouth)
4. ) Dizziness
5. ) Insomnia**

Question 5

SSRI: Contraindications [3]

[Citalopram, Escitalopram, Fluoxetine]

Answer 5

[Citalopram, Escitalopram, Fluoxetine]

1. ) MAOIs
2. ) Pimozide
3. ) Hypersensitivity

Question 6

SSRI: Contraindications [8]

[Fluvoxamine]

Answer 6

[Fluvoxamine]

1. ) MAOIs
2. ) Pimozide
3. ) Thioridazine
4. ) Alsetron
5. ) Astemizole
6. ) Terfenadine
7. ) Tizanidine
8. ) Hpyersensitivity

Question 7

SSRI: Contraindications [4]

[Paroxetine]

Answer 7

[Paroxetine]

1. ) MAOIs
2. ) Pimozide
3. ) Thioridazine
4. ) Hypersensitivity

Question 8

SSRI: Contraindications [5]

[Sertraline]

Answer 8

[Sertraline]

1. ) MAOIs
2. ) Pimozide
3. ) Disulfram-like compounds (oral concentrate)
4. ) Linezolid
5. ) Hypersensitivity

Question 9

SSRI: Contraindications [4]

[Vortioxetine]

Answer 9

[Vortioxetine]

1. ) MAOIs (within 21d)
2. ) Linezolid
3. ) Hypersensitivity
4. ) Methylene Blue

Question 10

SSRI: Contraindications [1]

[Vilazodone]

Answer 10

[Vilazodone]

MAOIs

Question 11

Monitoring Parameters: SSRIs (“Group 1”) [4]

[Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline]

Answer 11

1. ) Reduction/resolution of symptoms
2. ) Withdrawal symptoms from abrupt discontinuation
3. ) Abnormal bleeding
4. ) Worsening of depression/suicide/unusual behavior

Question 12

Monitoring Parameters: SSRIs [2]

[Vilazodone]

Answer 12

1. ) Reduction/resolution of symptoms

2. ) Worsening of depression/suicidality

Question 13

S/Sx: Depression (8)

Answer 13

Over SAME 2wk period:

1. ) Depressed mood (most of day, almost all days)
2. ) Marked diminished interest in pleasure in most activities
3. ) Significant weight loss/gain
4. ) Insomnia/hypersomnia
5. ) Psychomotor agitation/retardation
6. ) Fatigue/loss of energy nearly every day
7. ) Diminished ability to think/concentrate
8. ) Recurrent thoughts of death, suicide ideation

Question 14

MOA: SSRIs

Answer 14

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