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Psych Pharm > Antidepressants > Flashcards

Antidepressants Flashcards

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1
Q

SSRI

A

Selective Serotonin Reuptake Inhibitor
inhibits SERT
↑ serotonin action
Antidepressant

Adverse effects: 
Serotonin syndrome (sweating, shivering, tremors, hyperreflexia)
Suicidality
CYP450 inhibitor
CNS
Sexual dysfunction
weight gain or loss
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2
Q

SNRI

A

Serotonin & NE Reuptake Inhibitor
Inhibits SERT and NET
antidepressant
includes TCA class of drugs

TCA drugs also affect histamine, cholinergic and adrenergic receptors

similar adverse effects as SSRIs

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3
Q

TCA overdose

A

3 C’s

Coma

Cardiotoxicity (conduction abnormalities)

Convulsions

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4
Q

SARA

A

Serotonin Adrenergic Receptor Antagonist
antidepressant

Nefazodone and trazodone block post-synaptic 5-HTR and a1R

Mirtazapine blocks presynaptic a2R, and post-synaptic 5-HTR

Side effects → take in evening
Trazodone → CNS sedation, orthostatic hypotension
Mitrazapine → CNS sedation, weight gain

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5
Q

NDRI

A

NE and DA Reuptake Inhibitor
antidepressant

side effects
agitation and insomnia → take in morning
SEIZURES

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6
Q

MAOI

A

MonoAmine Oxidase Inhibitor
↑ NE, 5-HT, and DA
2 week washout period

same side effects as SSRIs

avoid foods high in tyramine (aged or fermented)
major concern is hypertensive crisis
-severe headache
-changes in vision
-nosebleeds
-chest pain
-SOB
-confusion
-tachycardia
-sweating/anxiety
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7
Q

esketamine

A

miscellaneous antidepressant

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8
Q

brexanolone

A

miscellaneous antidepressant

post-partum depression

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9
Q

Lithium

A

Mood stabilizer
Brain structure
Neurotransmitter modulation
intracellular changes

Adverse effects:
-Nephrogenic diabetes insipidus, ADH resistance, polyuria, polydipsia

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10
Q

Valproic acid/divalproex

A

mood stabilizer

bipolar I

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11
Q

Lamotrigine

A

mood stabilizer

Bipolar I and II

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12
Q

Carbamazepine

A

Mood stabilizer

Bipolar I

major CYP450 inducer

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13
Q

fluoxetine

A

SSRI

strong CYP450 inhibitor

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14
Q

vortioxetine

A

SSRI

least action on CYP450

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15
Q

escitalopram

A

SSRI

least action on CYP450

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16
Q

Citalopram

A

SSRI

17
Q

sertraline

A

SSRI

18
Q

vilazodone

A

SSRI

19
Q

paroxetine

A

SSRI

20
Q

Venlafaxine/Desvenlafaxine

A

SNRI

21
Q

Duloxetine

A

SNRI

22
Q

Levomilnacipran

A

SNRI

23
Q

Amitriptyline

A

SNRI

TCA

3

24
Q

Clomipramine

A

SNRI

TCA

3

25
Q

Doxepin

A

SNRI

TCA

3

26
Q

Imipramine

A

SNRI

TCA

3

27
Q

Amoxapine

A

SNRI

TCA

2

28
Q

Desipramine

A

SNRI

TCA

2

29
Q

Nortriptyline

A

SNRI

TCA

2

30
Q

Mirtazapine

A

SARA

31
Q

Nefazodone

A

SARA

32
Q

Trazodone

A

SARA

33
Q

Buproprion

A

NDRI

siezures

34
Q

Isocarboxazid

A

MAOI

35
Q

Phenelzine

A

MAOI

36
Q

Selegiline

A

MAOI

Selective

Psych Pharm (6 decks)

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