Anti-psychotics Flashcards
-azine
1st gen anti-psychotics
1st gen anti-psychotics
block receptors
- Muscarinic
- Histamine
- alpha adrenergic
- dopamine
side effects:
- muscarinic → dry mouth, constipation, urinary retention, blurred vision, sedation
- alpha-adrenergic → orthostatic hypotension, dizziness/syncope
- histamine → sedation
- dopamine → hyperprolactinemia, tardive dyskinesia
low potency 1st gen anti-psychotics
chlorpromazine
thioridazine
more sedation, hypotension, and seizure reduction
high potency 1st gen anti-psychotics
fluphenazine
haloperidol
more movement and endocrine effects (prolactin)
treatment for extrapyramidal side effects of 1st gen anti-psychotics
anticholinergics (benztropine and trihexyphenidyl)
antihistamine (diphenhydramine)
treatment for tardive dyskinesia side effect of 1st gen anti-psychotics
VMAT2 inhibitors
valbenazine
deutetrabenazine
2nd gen anti-psychotics
block 5-HT (and DA) receptors
side effects: weight gain and negative metabolic effects QTc prolongation/ECG changes stroke Neuroleptic malignant syndrome (NMS)
-idone
2nd gen anti-psychotics
5-HT/DA receptor antagonists
-piprazole
2nd gen anti-psychotics
partial DA/5-HT receptor antagonists
-apine
2nd gen anti-psychotic
multi-acting receptor-target agents
Pimavanserin
2nd gen anti-psychotic
used in patients with Parkinson’s Psychosis
treatment for NMS
Dantrolene
NMS → Malignant hyperthermia, muscle tetany, rhabdomyolysis
Tests to run before administering 2nd gen-antipsychotics
glucose, lipids, BMI, BP, waist circumference, FH of CV disease
how to manage nonadherence
Long Acting Injectable Agents
- haloperidol
- fluphenazine
- Risperidone
- Olanzapine
- Aripiprazole
