Antidepressants Flashcards
1
Q
Tricyclic antidepressants MOA
A
inhibit NA and 5-HT reuptake
2
Q
Tricyclic antidepressants ADRs
A
- antihistaminic, antimuscarinic effects
- orthostatic hypotension
- overdose: cardiac dysrhythmias
3
Q
MOA SSRIs
A
- block reuptake of 5-HT
4
Q
ADRs SSRIs
A
- insomnia, nausea, dizziness, anxiety
- increased suicide risk, serotonin syndrome (agitation, restlessness, confusion, rapid heart rate, high BP)
5
Q
uses of SSRIs
A
depression, anxiety, OCD
6
Q
MOA Tetracyclic antidepressants
A
block presynaptic alpha-2 receptors
7
Q
ADRs tetracyclic antidepressants
A
- sedation
- blood toxicity (rare)
8
Q
MOA NSRIs
A
- block reuptake of 5-HT, DA and NA
9
Q
ADRs NSRIs
A
- hypertension
- hypercholesterolaemia
- nausea, dizziness, insomnia
10
Q
MOA MAOIs
A
inhibit MAO
11
Q
ADRs non-selective MAOIs
A
- if high dietary tyramine, tyramine enters terminal via reuptake-1, causing massive release of NA = hypertensive CRISIS
12
Q
ADRs reversible inhibitors of MAO-A
A
- sleep disturbances, dizziness, nausea
more selective for 5-HT and NA, no dietary restrictions
13
Q
MOA SNRIs
A
primarily block NA uptake
14
Q
ADRs SNRIs
A
- dry mouth, constipation, tachycardia
15
Q
What level of depression is St John’s wort used for?
A
mild to moderate
