analgesics

Question 1

mechanism of opiods

Answer 1

activate u receptors = GPCR coupled to K+ channels, produces membrane hyperpolarisation, inhibit VACC

Question 2

ADRs of opioids

Answer 2

respiratory depression, dysphoria K-mediated, decreased gastric motility, nausea and vomiting, sedation, depression of cough reflex, pupil constriction, histamine effects as morphine causes histamine release from mast cells: hives - urticaemia, itching, bronchoconstriction, hypotension + dependence and tolerance

Question 3

MOA of paracetamol

Answer 3

blocks CNS COX, therefore no anti-inflammatory action

Question 4

ADRs of paracetamol

Answer 4

liver damage in overdose: antidote is N-acetylcysteine, a precursor of glutathione

Question 5

uses of paracetamol

Answer 5

mild-moderate pain relief, anti-pyretic, no anti-inflammatory action