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Antidepressants Flashcards

1
Q

Tricyclic antidepressants (2)

A

Nortriptyline

Amitriptyline

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2
Q

Nortriptyline: MOA

A

Inhibits SERT, NET

Blocks 5HT receptors

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3
Q

Nortriptyline: Indication

A

Depression

Off label: chronic pn, PTSD

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4
Q

Nortripltyline: side effects

A

Sexual dysfunction, long QT, anticholinergic effects

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5
Q

Nortriptyline: contraindications

A

Recent MI

MAOI use within 14 days

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6
Q

Remeron: class

A

Tetracyclic

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7
Q

Remeron: MOA

A

Disinhibits NE and 5HT release.

Blocks NE negative feedback loop.

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8
Q

Remeron: indication

A

Depression

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9
Q

Trazadone: class

A

SRI

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10
Q

Trazadone: MOA

A

5HT antagonist
Inhibits 5HT reuptake via SERT
Decrease number of 5HT-R

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11
Q

Trazadone: indication

A

MDD

Insomnia at lower doses

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12
Q

Trazadone: side effects

A

Very sedating
priapism
orthostatic HOTN

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13
Q

Trazadone: contraindication

A

Recent MI

other 5HT drugs

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14
Q

Trazadone uniquely binds ____ and ____ receptors

A

alpha 1

H1

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15
Q

Does Trazadone have a lot of anticholinergic effects?

A

Minimal

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16
Q

Name the SSRIs (6)

A 
Fluoxetine (Prozac)
Sertraline (Zoloft)
Citalopram (Celexa)
Escitalopram (Lexapro)
Fluvoxamine (Luvox)
Paroxetine (Paxil)
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17
Q

Fluoxetine (Prozac): MOA

A

Inhibits 5HT reuptake via SERT
Reduces 5HT-R numbers
M1 inhibition

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18
Q

Fluoxetine: indication

A 
MDD
dysphoric d/o
anxiety
OCD
eating d/o
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19
Q

Fluoxetine: contraindications

A

Seizure Hx, Platelet dysfunction, CVD

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20
Q

Fluoxetine: T 1/2

A

10 days

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21
Q

Sertraline (Zoloft): MOA

A

Selectively inhibits SERT and increases 5HT level in synapse

22
Q

Sertraline: indication

A 
MDD
PMDD
PD
PTSD
OCD
Social anxiety d/o
23
Q

Sertraline: contraindication

A

MAOI use within 14 days

Concomitant use of other 5HT drugs

24
Q

Does Sertraline raise prolactin levels?

A

Nope…no gynecomastia or galactorrhea here

25
Q

Citalopram (Celexa): MOA

A

Selectively inhibits SERT; mild antihistamine activity

26
Q

Citalopram: Indication

A

Depression

27
Q

SSRI: common side effects

A

Insomnia
Sexual dysfunction
Altered glucose control

28
Q

SSRI:
Stimulating
Middle of the road
Sedating

A

Stimulating: Fluoxetine, Sertraline
Middle of the road: Citalopram
Sedating: Paroxetine

29
Q

SNERIs (2)

A

Venlafaxine (Effexor)

Duloxetine (Cymbalta)

30
Q

Effexor: MOA

A

Inhibits SERT at lower doses and NET at higher doses

31
Q

Effexor: Indication

A 
MDD
GAD
SAD
panic disorder
Off label: pn, OCD, hot flashes)
32
Q

Cymbalta: MOA

A

Inhibits SERT and NET; increasing 5ht, NE, D

33
Q

Cymbalta: indication

A

MDD
Fibro
GAD
Chronic MSK pn

34
Q

Cymbalta: contraindication

A

MAOI use within 14 days
glaucoma
smoking

35
Q

SNERI: side effects

A 
Insomnia
Somnolence
Nervousness
Nausea
Dizziness
Sexual dysfunction
Hyperhydrosis
Abnormal dreams
36
Q

Phenelzine (Nardil): class

37
Q

Phenelzine: MOA

A

MAO inhibition increases 5HT, NE, and D

38
Q

Phenelzine: indication

A

Refractory depression

39
Q

Bupropion (Wellbutrin): class

A

Atypical antidepressant

40
Q

Bupropion: MOA

A

NE and D reuptake inhibition

41
Q

Bupropion: indication

A

Depression

smoking cessation

42
Q

The up side to Bupropion is…

A

Less sexual side effects

43
Q

Vortioxetine (Brintellux): class

A

5HT1-R agonist/5HT3-R antagonist

44
Q

Brintellux: MOA

A

Inhibits SERT

Partial 5HT agonist/antagonist

45
Q

Brintellux: indictaion

46
Q

Brintellux may also increase _____ risk

47
Q

Vilazodone (Viibryd): class

A

SSRI/5HT-R partial agonist

48
Q

Vilazodone: MOA

A

Inhibits SERT with elevation of 5HT levels.

49
Q

Does Vilazodone affect NE or D?

50
Q

Vilazodone: indication

Psych Pharm (4 decks)

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