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Psych Pharm > Addiction meds > Flashcards

Addiction meds Flashcards

1
Q

Acamprosate: class

A

GABA agonist/ Glutamate antagonist

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2
Q

Acamprosate: MOA

A

Increase GABA

Decrease Glutamate

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3
Q

Acamprosate: Indication

A

Maintenance of etoh cessation

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4
Q

Acamprosate: contraindications

A

CrCl below 30

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5
Q

Does Acamprosate cause a disulfram-like reaction?

A

No

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6
Q

Disulfram: class

A

Aldehyde Dehydrogenase Inhibitor

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7
Q

Disulfram:MOA

A

Inhibits etoh metabolism –> badness

Reisert shout-out

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8
Q

Disulfram: indication

A

Maintenance of etoh cessation

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9
Q

Disulfram: side effects

A

Psychosis, metallic or garlic taste, impotence, hepatitis

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10
Q

Minimum time needed to be abstinent before starting Disulfram?

A

12 hours

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11
Q

Naltrexone: class

A

Opioid antagonist

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12
Q

Naltrexone: MOA

A

Competative opioid antagonist. Highest affinity for mu.

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13
Q

Naltrexone: Indication

A

Maintenance of etoh/opioid cessation

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14
Q

Naltrexone: contraindication

A

Opioid in serum

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15
Q

What is required with a Naltrexone Rx?

A

FDA med guide

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16
Q

Methadone: class

A

Opioid analgesic

17
Q

Methadone: MOA

A

Inhibits ascending pn pathways; NMDA receptor antagonist

18
Q

Methadone: indication

A

Analgesia (low doses)

Opioid addiction Tx

19
Q

Methadone’s therapeutic window - narrow or wide?

20
Q

What should you avoid on Methadone?

21
Q

If you take Methadone for pn…

A

its effects will wear off faster than the t1/2

22
Q

Bupenorphine: class

A

Opioid partial agonist

23
Q

Bupenorphine: MOA

A

High affinity for mu receptors; partial kappa antagonism

24
Q

Bupenorphine: indication

A

Analgesia; opioid withdrawal/dependence

25
Q

What is required for a Bupenorphine Rx?

A

FDA med guide

26
Q

Naloxone: class

A

Opioid antagonist

27
Q

Naloxone: MOA

A

Pure competitive opioid antagonist

28
Q

Naloxone: indication

29
Q

Suboxone: class

A

Opioid partial agonist + opioid antagonist

30
Q

Suboxone: MOA

A

Combined bupenorphine/naloxone action

31
Q

Suboxone: indication

A

Maintenance therapy for opioid abstinence

32
Q

What does Suboxone use require?

A

Participation in FDA program and FDA med guide.

Psych Pharm (4 decks)

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