antidepressants Flashcards
Amitriptyline (Elavil®)
- tertiary amine
- Tricyclic Antidepressants (TCAs)
Imipramine (Tofranil®)
- tertiary amine
- Tricyclic Antidepressants (TCAs)
Nortriptyline (Pamelor®)
- secondary amine
- Tricyclic Antidepressants (TCAs)
Desipramine (Norpramin®)
- secondary amine
- Tricyclic Antidepressants (TCAs)
Phenelzine (Nardil®)
Monoamine Oxidase Inhibitors (MAOIs)
Selegiline (Deprenyl®)
Monoamine Oxidase Inhibitors (MAOIs)
Fluoxetine (Prozac®)
Selective Serotonin Reuptake Inhibitors (SSRIs)
Paroxetine (Paxil®
Selective Serotonin Reuptake Inhibitors (SSRIs)
Sertraline (Zoloft®)
Selective Serotonin Reuptake Inhibitors (SSRIs)
Citalopram (Celexa®
Selective Serotonin Reuptake Inhibitors (SSRIs)
Venlafaxine (Effexor®)
5-HT and NE Reuptake Inhibitors (SNRIs)
Duloxetine (Cymbalta®)
5-HT and NE Reuptake Inhibitors (SNRIs)
which neurotransmitter is responsible for reward, motivation, euphoria, and movement
dopamine
which neurotransmitter is responsible for reward, arousal, alertness, decisions, and flight or fright
NE/noradrenaline
which neurotransmitter is responsible for mood, emotion, memory, sleep, and cognition
serotonin (5-HT)
what is the Monoamine Hypothesis of depression
- amine neurotransmitters are DA, NE, and serotonin
- depression results from abnormal or decressed neurotransmission of dopamine, norepinephrine and serotonin
evidence for the Monoamine Hypothesis is that patients treated with Reserpine which depletes neurons of noradrenaline (NE) and serotonin (5-HT) developed what
- depression
* This suggested that depression had something to do with a deficit of NE and 5-HT.
the antidepressant effect takes 2-3 weeks due to
neural plasticity
differentiate between short term effects and long term effects of uptake inhibitors
- Normal - amine levels in synapse are modulated by reuptake and presynaptic inhibition
- short term Uptake inhibitors - amine levels in synapse are increased BUT so does feedback inhibition so synaptic amine levels are balanced
- Long-term - Antidepressants downregulate auto-receptors (which control firing rate of neuron by negative feedback); increasing firing rate of amine neurons
MOA of tricyclic antidepressants
- inhibit re-uptake of NE and serotonin
- also block a-adrenergic, histamine and muscarinic receptors
list uses of tricyclic antidepressants
- depression: not first line
- chronic pain (TMJ)
List the tertiary amines TCA
- amitriptyline (Elavil®)
- imipramine (Tofranil®)
MOA of tertiary amines. adverse effects?
- primarily inhibit serotonin re-uptake
- produce more seizures and are more sedating than secondary amines
List the secondary amines TCA
- nortriptyline (Pamelor®)
- desipramine (Norpramin®)
MOA of secondary amine TCA
primarily block NE re-uptake
List the 4 dopamine pathways
- nigrostriatal
- mesolimbic
- mesocortical
- tubero-infundibular