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U3 Pharm > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

Tranylcypromine

  • class
  • use
  • side effect
  • similar drug
A

Irreversible inhibites MAOa and b

  • MAOI
  • depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
  • hypertensive crisis (tyramine), serotonin syndrome, agitation, delirium, seizure
  • phenelzine
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2
Q

Desipramine

  • class
  • use
  • side effect
  • similar drug (3)
A

blocks reuptake of NE and 5HT

  • TAC
  • depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
  • sympathomimetic
  • imipramine, amitriptyline, nortriptyline
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3
Q

Fluxetine

  • class
  • use
  • side effect
  • similar drug (4)
A

inhibit reuptake of 5HT

  • SSRI
  • depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
  • serotonin syndrome
  • paroxetine, sertraline, excitalopram, citalopram
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4
Q

Duloxetine

  • class
  • use
  • side effect
  • similar drug
A

Inhibit reuptake of NE

  • SNRI
  • depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
  • sympathomimetic
  • venlafaxine
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5
Q

Bupropion

  • class
  • use
  • side effect
A

Blocks DA and NE reuptake

  • atypical
  • depression, anxiety, etc, quit smoking
  • lowers seizure threshold
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6
Q

Mirtazapine

  • class
  • use
  • side effect
A

5HT2 antagonist

  • atypical
  • depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
  • lower seizure threshold
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7
Q

Diazepam

  • class
  • use
  • side effect
  • similar drug
A

Long acting GABAa agonist with active metabolites

  • benzodiazepine
  • short-term depression, bipolar, anticonvulsant, muscle relaxant
  • CNS depression, tolerance, dependence/withdrawal, drug interactions
  • chlordiazepoxide, flurazepam
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8
Q

Midazolam

  • class
  • use
  • side effect
  • similar drug
A

short acting GABAa agonist

  • benzo
  • pre-op sedation and anesthesia
  • -CNS depression, tolerance, dependence/withdrawal, drug interactions
  • Triazolam
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9
Q

Alprazolam

  • class
  • use
  • side effect
  • similar drug
A

long acting GABAa agonist without active metabolites

  • benzo
  • anxiety, panic, phobia, epilepsy
  • -CNS depression, tolerance, dependence/withdrawal, drug interactions
  • Lorazepam
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10
Q

Zolpidem

  • class
  • use
  • side effect
  • similar drug
A

non-benzo receptor agonist

  • BDZ1 selective agonist
  • sedation, hypnosis w/o muscle relaxant/anticonvulsion
  • sleep walking, next day impairment
  • zolpiclone, zolepon
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11
Q

Thiopental

  • class
  • use
  • side effect
  • similar drug
A

GABA agonist

  • barbituate
  • inducing anesthesia, anticonvulsant
  • critical drug interactions, fatal CNS depression with OD
  • phenobarbital
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U3 Pharm (7 decks)

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