antidepressants Flashcards
1
Q
tranylcypromine
A
- MAOI
- irreversibly inhibit MAOa and MAOb
- hypertensive crisis with tyramine
- serotonin syndrome with SSRI
2
Q
Phenelzine
A
- MAOI
- inhibits both MAOa and MAOb
- hypertensive crisis with tyramine (MAOI also inhibit the metabolism of tyramine which is a precursor of NE –> too much tyramine –> too much NE)
- serotonin syndrome with SSRI
3
Q
Desipramine
A
- tricyclic
4
Q
tricyclics
A
”–amine” and “–triptyline”
- amine reuptake inhibitor
- dirty drugs: block muscarinic, alpha adrenergic and histamine receptors (blurred vision, hypotension, sedation)
- cardiac arrhythmias, conduction defects (also due to alpha-adrenergic blockade)
- have active metabolites –> wide duration of effect
5
Q
Imipramine
A
tricyclic
6
Q
amitriptyline
A
tricyclic
7
Q
nortriptyline
A
tricyclic
8
Q
fluoxetine (prozac)
A
- SSRI
- inhibit P450 enzymes drug-drug interactions
9
Q
Paroxetine (paxil)
A
- SSRI
- inhibit P450’s: drug-drug interactions (will result in higher levels of another drug)
10
Q
sertraline (zoloft)
A
SSRI
11
Q
escitalopram (lexapro)
A
SSRI
12
Q
citalopram
A
SSRI
13
Q
duloxetine (cymbalta)
A
SNRI
14
Q
venlafaxine
A
SNRI
15
Q
properties of SSRI (advantages and disadvantages)
A
- not any more effective that tricyclics
- (+): longer duration of action, no seizures, cardiac arrhythmias
- (-): Nausea, sexual dysfunction, drug-drug interactions (inhibit p450 enzymes), serotonin syndrome with MAOI
