Antidepressants Flashcards

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1
Q

Serotonin Syndrome
Mental Symptoms
(8)

A
  • excitation
  • agitation
  • anxiety
  • headache
  • disorientation
  • hallucinations
  • coma
  • seizures are pre-terminal
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2
Q

Serotonin Syndrome
Neuromuscular Abnormalities
(7)

A
  • tremors
  • inducible/spontaneous clonus
  • muscle rigidity (esp. lower limbs)
  • ocular clonus (ping pong gaze)
  • hyperreflexia
  • bilateral babinski
  • akisthesia
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3
Q

Serotonin Syndrome
Autonomic Hyperactivity

A
  • tachycardia
  • hypetension
  • tachypnoea
  • dysrhythmias
  • hyperthermia
  • flushed skin
  • diaphoresis
  • hydriasis
  • dry muscous membranes
  • vomiting/diarrhoea
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4
Q

Definition
Autonomic Hyperactivity

A

arousal of the autonomic nervous system, particularly its sympathetic nervous system functions, resulting in the physiological symptoms associated with anxiety and fear

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5
Q

Serotonin Syndrome
Hunter Criteria
(5)

A

pt must have takeb serotonergic medication and have one of the below lines of symptoms

  • spontaneous clonus
  • inducible clonus PLUS agitation/diaphoresis
  • occular clonus PLUS agitation/diaphoresis
  • tremor PLUS hyperreflexia
  • hypertonic PLUS temp >38 PLUS occular clonus/inducible clonus
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6
Q

Tricyclic Antidepressant Toxidrome
Neuro Symptoms
(5)

A
  • agitation
  • ALOC
  • seizures
  • coma
  • CNS depression (leading to resp depression)
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7
Q

Tricyclic Antidepressant Toxidrome
Cardio Symptoms
(5)

A
  • transient early hypertension
  • hypotension
  • othostasis
  • resting tachycardia
  • peripheral vasodilation
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8
Q

Tricyclic Antidepressant Toxidrome
ECG findings
(6)

A
  • PR, QRS, QT widening
  • R axis deviation
  • tall terminal R in aVR
  • tachy
  • dysrhythmias
  • VT/VF
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9
Q

Tricyclic Antidepressant Toxidrome
Peripheral Symptoms
(7)

A
  • hot & dry
  • mydriasis
  • dry mucosa
  • fever
  • constipation
  • delayed gastric emptying
  • decreased bowel sounds
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10
Q

Diagnose

A

TCA Toxicity

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11
Q

MAOI Toxidrome
Neuro Symptoms
(5)

A
  • ocular clonus
  • agitation
  • ALOC
  • seizures
  • coma
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12
Q

MAOI Toxidrome
Cardio Symptoms
(2)

A
  • significant hypertension
  • tachycardia
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13
Q

MAOI Toxidrome
ECG Findings

A
  • tachycardia
  • tachyarrhythmias
  • ischaemic changes
  • hyperkalaemia
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14
Q

Potassium ECG Findings
Hyperkalemia
(4)

A
  • widened QRS
  • wide, flat P-Wave
  • prolonged PR Interval
  • tall, peaked T wave
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15
Q

Potassium ECG Findings
Hypokalemia
(2)

A
  • prolonged U wave
  • T wave inverts
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16
Q

Hyperkalemia
Treatment Plan

A
  • consider safety, QPS back-up and sedation
  • airway suction? secretion and mucous likely