Antidepressants Flashcards
Serotonin Syndrome
Mental Symptoms
(8)
- excitation
- agitation
- anxiety
- headache
- disorientation
- hallucinations
- coma
- seizures are pre-terminal
Serotonin Syndrome
Neuromuscular Abnormalities
(7)
- tremors
- inducible/spontaneous clonus
- muscle rigidity (esp. lower limbs)
- ocular clonus (ping pong gaze)
- hyperreflexia
- bilateral babinski
- akisthesia
Serotonin Syndrome
Autonomic Hyperactivity
- tachycardia
- hypetension
- tachypnoea
- dysrhythmias
- hyperthermia
- flushed skin
- diaphoresis
- hydriasis
- dry muscous membranes
- vomiting/diarrhoea
Definition
Autonomic Hyperactivity
arousal of the autonomic nervous system, particularly its sympathetic nervous system functions, resulting in the physiological symptoms associated with anxiety and fear
Serotonin Syndrome
Hunter Criteria
(5)
pt must have takeb serotonergic medication and have one of the below lines of symptoms
- spontaneous clonus
- inducible clonus PLUS agitation/diaphoresis
- occular clonus PLUS agitation/diaphoresis
- tremor PLUS hyperreflexia
- hypertonic PLUS temp >38 PLUS occular clonus/inducible clonus
Tricyclic Antidepressant Toxidrome
Neuro Symptoms
(5)
- agitation
- ALOC
- seizures
- coma
- CNS depression (leading to resp depression)
Tricyclic Antidepressant Toxidrome
Cardio Symptoms
(5)
- transient early hypertension
- hypotension
- othostasis
- resting tachycardia
- peripheral vasodilation
Tricyclic Antidepressant Toxidrome
ECG findings
(6)
- PR, QRS, QT widening
- R axis deviation
- tall terminal R in aVR
- tachy
- dysrhythmias
- VT/VF
Tricyclic Antidepressant Toxidrome
Peripheral Symptoms
(7)
- hot & dry
- mydriasis
- dry mucosa
- fever
- constipation
- delayed gastric emptying
- decreased bowel sounds
Diagnose
TCA Toxicity
MAOI Toxidrome
Neuro Symptoms
(5)
- ocular clonus
- agitation
- ALOC
- seizures
- coma
MAOI Toxidrome
Cardio Symptoms
(2)
- significant hypertension
- tachycardia
MAOI Toxidrome
ECG Findings
- tachycardia
- tachyarrhythmias
- ischaemic changes
- hyperkalaemia
Potassium ECG Findings
Hyperkalemia
(4)
- widened QRS
- wide, flat P-Wave
- prolonged PR Interval
- tall, peaked T wave
Potassium ECG Findings
Hypokalemia
(2)
- prolonged U wave
- T wave inverts