Anticonvulsant Drugs

Question 1

Lamotrigine

1) Use
2) Mechanism of Action

Answer 1

1) Focal, Tonic clonic, absence seizures
2) Voltage-gated Na+ channel inhibitor
* Drug of Choice*

Question 2

Valproate

1) Use
2) Mechanism of Action

Answer 2

1) Tonic clonic, myoclonic, absence seizures
2) Voltage-gated Na+ channel inhibitor
* Drug of Choice*

Question 3

Fosphenytoin

1) Use
2) Mechanism

Answer 3

1) Status Epilepticus
2) Voltage-gated Na+ channel inhibitor
* Drug of ChoiceProdrug for Phenytoin

Question 4

Carbamazepine

1) Use
2) Mechanism

Answer 4

1) Focal seizures

2) Voltage-gated Na+ channel inhibitor

Question 5

Oxcarbazepine

1) Use
2) Mechanism of Action

Answer 5

1) Focal seizures
2) Voltage-gated Na+ channel inhibitor
* No CYP metabolism*

Question 6

Topiramate

1) Use
2) Mechanism of Action

Answer 6

1) Tonic clonic, myoclonic seizures
2) Voltage-gated Na+ channel, Ca2+ channel inhibitor and Activates GABAa
* Birth control less effective*

Question 7

Zonisamide

1) Use
2) Mechanism of Action

Answer 7

1) Tonic clonic, myoclonic seizures

2) Voltage-gated Na+ channel inhibitor

Question 8

Leviteracitam

1) Use
2) Mechanism of Action

Answer 8

1) Focal, Tonic clonic, Myoclonic seizures
2) Voltage-gated Ca2+ channel inhibitor
* Drug of Choice*

Question 9

Ethosuximide

1) Use
2) Mechanism of Action

Answer 9

1) Absence seizures
2) Voltage-gated Ca2+ channel inhibitor
* Drug of Choice*

Question 10

Lorazepam

1) Use
2) Mechanism of Action

Answer 10

1) Status Epilepticus
2) Binds between alpha and gamma subunits on GABAa receptor to hyper-polarize the neuron and prevent AP
* Drug of Choice*

Question 11

Phenobarbital

1) Use
2) Mechanism of Action

Answer 11

1) LAST RESORT for Status Epilepticus
2) Binds on Beta subunit on GABAa receptor to hyper-polarize the neuron and prevent AP
* Low therapeutic index=Toxic*