Anticoagulants, antiplatelets, and thrombolytics Flashcards
Is heparin an anticoagulant or antiplatelet?
Anticoagulant
Is Ticagrelor (brilinta) an anticoagulant or antiplatelet?
Antiplatelet
Is Bivalirudin an anticoagulant or an antiplatelet?
Anticoagulant
Is Dabigatran (Pradaxa) an anticoagulant or an antiplatelet?
Anticoagulant
Is warfarin (coumadin) an anticoagulant or an antiplatelet?
Anticoagulant
Is Clopidogrel (plavix) an anticoagulant or an antiplatelet?
Antiplatelet
Is aggrastat an anticoagulant or an antiplatelet?
Antiplatelet
Is Rivaroxaban (Xarelto) an anticoagulant or an antiplatelet?
Anticoagulant
Is apixaban (eliquis) an anticoagulant or an antiplatelet?
Anticoagulant
Is low molecular weight heparin an anticoagulant or an antiplatelet?
Anticoagulant
What is intravenous glycoprotein IIb/IIa inhibitor/ antiplatelet called?
Tirofiban
What is the loading dose for tirofiban?
25mcg/kg over five minutes or less
What is the Intravenous anticoagulant/direct thrombin inhibitor. The MAG states it is used in cath lab and during a CABG surgery.
Bivalirudin
What are the complications for thrombolytic medications?
- bleeding
- reperfusion dysrhythmias
- stroke
What are the indications for heparin sodium?
- prevent clot formation
- prevent venous thromboembolism
- early treatment of unstable angina, ACS, and acute MI
- stroke
What are heparin sodium’s actions?
Indirect thrombin inhibitor, does not lyse clots.
What are the contraindications when using heparin sodium along with other anticoagulants?
- doesn’t mix well with other medications or herbal supplements (garlic).
- aneurysm
- coagulopathy
- hepatic disease
- PUD
- pregnancy
What are the complications if protamine sulfate is given too fast?
- hypotension
- bleeding
- dyspnea
- sinus bradycardia
What are the two direct thrombin inhibitors?
Tenecteplase (IV) and altepase (oral)
What are the actions of tenecteplase?
Bind to fibrin and convert plasminogen to plasmin
What are the actions of warfarin?
Anticoagulant and vitamin K antagonist
What is the classification of argatroban?
Anticoagulant (direct thrombin inhibitor)
Why might we give argatroban over heparin sodium?
When there are hepatic issues.
What are the indications for using Rivaroxaban (Xarelto) and apixaban (eloquis)?
- Non vascular atrial fibrillation
- PE treatment
- DVT prophylaxis
What are the adverse side effects from clopidogrel (plavix)?
- bleeding
- pruritis
- epistaxis
- hematoma
- TTP
What is the antidote for heparin sodium? (LMWH)
Protamine sulfate
What is the antidote for warfarin? (Coumadin)
K Central
What is the antidote for Dabigatran? (Pradaxa)
Praxbind
What is the antidote for Rivaroxaban (Xarelto) and Apixaban (eloquis)?
Andexxa
