Anticoagulants 2 Flashcards
1
Q
Warfarin
MOA
Indications
Adverse
A
MOA
competitive antagonist of vitamin K. suppresses the functional synthesis of 2 7 9 10, monitored by PT/INR
Indications
Prolonged treatment of DVT and Atrial Fibrillation
Adverse
- Bleeding
- Coumadin induced necrosis
- drug interactions (potentiate warfarin)
2
Q
Vitamin K
MOA
Indication
Adverse
A
MOA
cofactor in the synthesis of functional forms of 2, 7, 9, 10
Indications
Hypoprothrombinemia, intestinal disorders and gastrectomy, reverse effects of warfarin
Adverse:
Hemolysis
3
Q
Rivaroxaban/Apixaban
MOA
Indication
Advrse
A
MOA
Oral anti 10a
Indications:
Stroke prevention in patients with atrial fibrillation
Rivaroxaban also approved for prophylaxis and treatment of DVT
Adverse:
Bleeding and liver tox
4
Q
Dabigatran
A
MOA Inhibits 2a (thrombin)
Indication:
Stroke prevention in patients with atrial fibrillation
Adverse:
Bleeding and liver tox
