Anticoagulants 1

Question 1

Heparin
MOA
Route of administration 
Indication 
Adverse Effects

Answer 1

MOA
Complex with AT and inhibit factors 10a and 2a. Monitored by APTT(2-2.5)

Route of Administration
Mainly IV
Also subcutaneous

Indication:
Surgical Anticoagulation

Adverse Effects:

1. Bleeding
2. HIT
3. Osteoporosis
4. Alopecia

Question 2

Low Molecular Weight Heparins

Answer 2

MOA
Complex with AT and inhibits factors 10a and 2a-monitored by 10a

Route
Subcutaneous

Indication:
Prophylaxis and Treatment of DVT and ACS

Adverse:
Bleeding

Question 3

Fondaparinux

Pentasaccharide

Answer 3

MOA
Complex with AT and inhibit 10a

Route
Subcutaneous

Indication:
DVT

Adverse:
Bleeding

Question 4

Argatroban/Bivalirudin/Hirudin

Answer 4

MOA
Directly inhibits 2a

Route
IV

Indication:
HIT

Adverse:
Bleeding

Question 5

Antithrombin Concentrate

Answer 5

MOA
Directly inhibits 2a

Route:
IV

Indication:
DIC, sepsis, thrombophilia, hypercoagulable state

No adverse

Question 6

Protamine Sulfate

Answer 6

MOA
Heparin antagonist

Route
IV

Indication:
Reversal for Heparin

Adverse:

1. Bradycardia
2. Hypotension