Anticoagulants Flashcards
What is the dose range for warfarin
-5-20mg initially, maintenance is 3-9mg daily.
What is the duration of DVT treatment with warfarin
6 months
What is the duration of VTE treatment with warfarin, provoked by an oral combined contraceptive
3 months
What is the duration of treatment of VTE with warfarin, caused by AF
6 months to Long term
What is the apixaban dose for recurrent VTE and prophylaxis following surgery
1) 2.5mg BD ✔
2) 5mg BD
3) 10mg BD for 7 days, then 5mg BD
4) 2.5mg OD
What is the apixaban dose for the treatment of VTE
1) 2.5mg BD
2) 5mg BD
3) 10mg BD for 7 days, then 5mg BD ✔
4) 2.5mg OD
What is the apixaban dose for non-valvular AF
1) 2.5mg BD
2) 5mg BD ✔
3) 10mg BD for 7 days, then 5mg BD
4) 2.5mg OD
Which factor would not require the non-valvular AF dose of apixaban to be reduce to 2.5mg BD
1) Over 80 years old
2) Less than 60KG
3) Creatinine clearance 15-29
4) Creatinine less than 133 ✔
What is the standard dose of edoxaban
1) 60mg BD
2) 60mg OD ✔
3) 30mg OD
4) 30mg BD
Which factor would not cause the dose of edoxaban to be reduced to 30mg OD
1) Less than 60KG
2) Crcl 15-50
3) Over 80 years old ✔
4) Taking concomitant PgP inhibitor
Which drug would not require the dose of edoxaban to be reduced, if taken at the same time
1) Verapamil
2) Amiodarone/dronedarone
3) Saint Johns Wort ✔
4) Ciclosporin
5) Erythromycin
6) Ketoconazole
What is the dose of rivaroxaban for prophylaxis after knee and hip surgery?
-10mg OD for 2 weeks (Knee) or 5 weeks (Hip)
What is the dose of rivaroxaban for VTE treatment?
-15mg OD for 21 days then20mg OD
What is the dose of rivaroxaban for VTE prophylaxis?
-10-20mg OD following 6 months of anticoagulation
What is the rivaroxaban dose for non-valvular AF with at least 1 risk factor?
-20mg OD
