Anticholinergic (Parasympatholytic) Bronchodilators

Question 1

• Anticholinergic bronchodilator

Answer 1

Agent that blocks parasympathetic nervous fibers and muscarinic receptors from being stimulated, allowing relaxation of smooth muscle in the airway.

• Anticholinergic agents given by inhalation are a second class of bronchodilating agents.

• Anticholinergic agents, also known as muscarinic antagonists, are often separated in to short-acting muscarinic antagonists (SAMAs) and long-acting muscarinic antagonists (LAMAs).

Question 2

-Anticholinergic Effects:

Answer 2

• Urinary retention

Question 3

• Anticholinergic Side effects:

Answer 3

• Dry mouth (most common)

• When administered SVN: in addition to dry mouth…pharyngitis, dyspnea, flulike symptoms, bronchitis, upper respiratory infection

Question 4

Inhaled Anticholinergic Bronchodilator Agent
Ipratropium bromide: (the only SAMA!)

Answer 4

Ipratropium bromide: (the only SAMA!)

• Trade name - Atrovent

• Generic name - Ipratropium bromide

• Duration: 6 hrs

-Only SAMA with SVN

Question 5

• Ipratropium bromide and albuterol (SAMA and SABA combo)

Answer 5

• Trade name - Combivent Respimat (inhaler version)

• Generic name - ipratropium bromide and albuterol

• Trade name - DuoNeb (small volume neb solution)

• Generic name - ipratropium bromide and albuterol

Question 6

Inhaled Anticholinergic Bronchodilator Glycopyrrolate bromide

Agents: LAMA’s

Answer 6

• Glycopyrrolate bromide

• Trade name: Seebri Neohaler, Lonhala Magnair,

• Generic name: Glycopyrrolate bromide

• Duration: 12 hr

Question 7

• Umeclidinium bromide LAMA

Answer 7

• Trade name: Incruse Ellipta

• Generic name: Umeclidinium bromide

• Duration: 24 hr

Question 8

Revefenacin LAMA

Answer 8

• Trade name: Yupelri

• Generic name: Revefenacin

• Duration: 24 hr

Question 9

Atropine

Answer 9

• Tertiary compound

• had been administered as a nebulized solution

• this agent is no longer commonly aerosolized

Question 10

Atropine

• Used for the following purposes:

Answer 10

• as bronchodilators

• for drying secretions preoperatively

• for reversal of bradycardia

• for pupillary dilation (mydriasis)

Question 11

Atropine

• Side effects:

Answer 11

• dried secretions

• mucus plugging

Question 12

Combo Drugs

Answer 12

-There are LABA and LAMA combo drugs

Question 13

LAMA Tiotropium Bromide

Answer 13

TN: Spiriva

GN: Tiotropium Bromide