Anticestodal Drugs

Question 1

What treats Anoplocephala perforliata in horses

Answer 1

Praziquantel and ivermectin**
Pyrantel Pamoate

Question 2

Taeniafuges

Answer 2

Facilitates tapeworm expulsion from the host
Ex: Aercoline

Question 3

Aercoline

Answer 3

Muscarinic Agonist
MOA: spastic paralysis and↑ host gut motility

Question 4

Taeniacides

Answer 4

Causes death of the tapeworm in situ

Question 5

Praziquantel

Answer 5

Synthetic isoquinolinepyrazine derivative
Tablet, SC/IM, combined

Question 6

Safety/ toxicity of praziquantel

Answer 6

Wide margin of safety
Breeding and pregnant animals safe

Question 7

Praziquantel PK

Answer 7

Low oral bioavailibility
Metabolite in dogs: 4-hydroxy-praziquantel
Renal excretion

Question 8

Praziquantel MOA

Answer 8

Rapid and sustained paralytic muscle contraction of the parasite
Tegumental disruption
Alteration of Ca2+ homeostasis

Question 9

Praziquantel uses

Answer 9

Cestode and trematodes (schisosomiasis liver and lung fluke)
Adult tapeworms
Larval form of cestodes

Question 10

Specific parasites Praziquantel used for

Answer 10

All stages of Taenia
E. granulosus elimination (dogs)
Cestodes of sheep/goats (Moniezia, stilesia, avitellina)
Anoplocephala perfoliata in horses (intestinal tapeworms)

Question 11

Emodepside MOA

Answer 11

Activates presynaptic secretion receptors resulting in paralysis and death of parasite

Question 12

Emodepside uses

Answer 12

Roundworms (adult and immature) and tapeworms (adult) in cats
Queens during late preg. For Toxocara cati

Question 13

Epsiprantel

Answer 13

Same MOA as Praziquantel
Treats tapeworms of dogs (D. caninum and T. pisiformis) and cats D. caninum and T. formis)

Question 14

Epsiprantel PK

Answer 14

Oral admin in dogs and cats
Poorly absorbed in GI
Eliminated in feces

Question 15

Epsiprantel adverse

Answer 15

Safe drug → emesis most common side effect in cats with prolonged tx and high doses