Antibodies

Question 1

Anti-Ro60 (SSA)

Answer 1

Sjogrens, SLE, neonatal heart block

Question 2

Anti-La (SS-b)

Answer 2

Sjogen’s

Question 3

Anti-centromere

Answer 3

Limited scleroderma/CREST

Question 4

Anti-dsDNA

Answer 4

SLE

Question 5

Anti-Jo1

Answer 5

Polymyositis

Question 6

Anti-U1RNP

Answer 6

Mixed connective tissue disease

Question 7

Anti-Smith

Answer 7

SLE, specific

Associated with renal and neurological lupus

Question 8

Anti-topoisomerase (Anti-SCL70)

Answer 8

Scleroderma, associated with ILD

Question 9

Anti-histone

Answer 9

SLE, drug induced lupus

Question 10

Anti-CCP

Answer 10

RA, specific

Question 11

Rheumatoid factor

Answer 11

RA

Question 12

Anti-thrombin

Answer 12

SLE

Question 13

C-ANCA (PR3)

Answer 13

GPA/Wegener’s

Question 14

P-ANCA (MPO)

Answer 14

MPA, EGPA

Question 15

Anti-SRP

Answer 15

Polymyositis - highly aggressive, poor response to immunosuppression

Can also be seen in necrotizing autoimmune myositis

Question 16

Anti-RNA polymerase III

Answer 16

Scleroderma, associated with renal disease

Question 17

Anti-ro52

Answer 17

Scleroderma, ILD, dermatomyositis

Question 18

Anti-p155

Answer 18

Dermatomyositis - Associated with malignancy, severe cutaneous involvement

Question 19

Anti-HMGCR

Answer 19

Statin induced necrotising myositis

Question 20

BAFF + IL6

Answer 20

GCA/PMR

Question 21

Anti-TTG

Answer 21

Coeliac

Question 22

Anti-etg

Answer 22

Dermatitis herpetiformis

Question 23

Anti-actin

Answer 23

Coeliac

Question 24

Anti-LKM-1

Answer 24

Autoimmune hepatitis

Question 25

Anti-SMA

Answer 25

Chronic autoimmune hepatitis

Question 26

AMA

Answer 26

Primary biliary cirrhosis

Question 27

ASCA

Answer 27

Crohn's

Question 28

Anti-GQ1B

Answer 28

Miller-fischer syndrome

Question 29

Anti GD3

Answer 29

Acute motor axonal neuropathy

Question 30

Anti GM1

Answer 30

MMN with conduction block

Question 31

Anti-AChR

Answer 31

Myasthenia gravis

Question 32

Anti-MUSK

Answer 32

Myasthenia Gravis (not seen in ocular) Often bulbar changes More likely to respond to rituximab Not associated with thymoma

Question 33

Anti-LRP4

Answer 33

Myasthenia Gravis (mild-mod)

Question 34

Anti-VGCC (voltage gated calcium channel)

Answer 34

Lambert eaton myasthenic syndrome

Question 35

Anti-Hu

Answer 35

SCLC, Neuroblastomas Paraneoplastic cerebellar degeneration, limbic encephalitis, encephalomyelitis, subacute sensory neuronopathy, choreathetosis, myoclonus

Question 36

Anti-Yo

Answer 36

Ovarian and breast ca | Paraneoplastic cerebellar degeneration

Question 37

Anti-ma

Answer 37

Testicular and lung cancer | Encephalomyelitis, Limbic encephalitis

Question 38

Anti-Ri

Answer 38

Opsoclonus myoclonus syndrome

Question 39

Anti-Tr

Answer 39

Paraneoplastic cerbellar syndrome

Question 40

Anti-amphiphysinn

Answer 40

Stiff person syndrome, paraneoplastic cerebellar degeneration

Question 41

Anti-GAD

Answer 41

T1DM | Breast, CRC, SCLC - Stiff man syndrome

Question 42

Anti-VGKC

Answer 42

Limbic encephalitis,

Question 43

Anti-CRMP-5

Answer 43

Optic neuropathy, chorea

Question 44

Anti-NMDAr

Answer 44

Anti-NMDA receptor encephalitis

Question 45

Anti-aquaporin 4

Answer 45

Neuormyelitis optica (also called Anti-NMO)

Question 46

Anti-cardiolipin

Answer 46

Antiphospholipid

Question 47

Anti beta-2-glycoprotein-1

Answer 47

Antiphospholipid

Question 48

Anti-PF4 (platelet factor 4)

Answer 48

Heparin induced thrombocytopaenia

Question 49

Anti-TPO

Answer 49

Hashimoto's thyroiditis, Grave's disease

Question 50

Anti-Tg

Answer 50

Hashimoto's thyroiditis

Question 51

Anti-TRabs

Answer 51

Grave's disease

Question 52

Anti PLA2R

Answer 52

IgG4 Ab Membranous GN, 80% primary membranous, good response to rituximab

Question 53

Anti-THSD7A

Answer 53

Membranous GN

Question 54

suPAR (Soluble urokinase type plasminogen activator receptor)

Answer 54

Focal segmental glomerulosclerosis

Question 55

Anti-GBM

Answer 55

Goodpasture's disease - RPGN + pulmonary haemorrhage

Question 56

c904G72

Answer 56

Frontotemporal dementia/Motor neuron disease

Question 57

Alpha synucleinopathies

Answer 57

Parkinson's, Multisystem atrophy, DLB

Question 58

Tauopathies

Answer 58

Alzheimers, Progressive supranuclear palsy, Frontotemporal dementia

Question 59

TARDBP gene

Answer 59

FTD

Question 60

Anti-cardiolipin

Answer 60

Antiphospholipid

Question 61

Anti-PS/PT

Answer 61

Antiphospholipid, small proportion of seronegative APLS

Question 62

Anti- Mi2

Answer 62

Dermatomyositis Shawl rash particularly Better prognosis Less cancer incidence

Question 63

Anti-MDA5

Answer 63

Dermatomyositis, cutaneous features predominantly | Higher risk if oral pain/ulceration, arthritis/arthralgia

Question 64

Anti-TIF1y association

Answer 64

Dermatomyositis | Strong association with malignancy

Question 65

Anti-cN1A association

Answer 65

Inclusion body myositis

Question 66

Anti-GAD65

Answer 66

T1DM

Question 67

Anti-IA-2

Answer 67

T1DM

Question 68

Anti PL7 and PL12

Answer 68

Anti-synthetase syndrome

Question 69

Anti-Ku

Answer 69

Scleroderma with myositis

Question 70

Anti-DFS70 association

Answer 70

Positive result means unlikely to be SLE

Question 71

Anti-NXP-2 | Nuclear matrix protein

Answer 71

Increased risk of malignancy in dermatomyositis