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Basic Physician's Training Monash > Antibodies > Flashcards

Antibodies Flashcards

1
Q

Anti-Ro60 (SSA)

A

Sjogrens, SLE, neonatal heart block

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2
Q

Anti-La (SS-b)

A

Sjogen’s

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3
Q

Anti-centromere

A

Limited scleroderma/CREST

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4
Q

Anti-dsDNA

A

SLE

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5
Q

Anti-Jo1

A

Polymyositis

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6
Q

Anti-U1RNP

A

Mixed connective tissue disease

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7
Q

Anti-Smith

A

SLE, specific

Associated with renal and neurological lupus

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8
Q

Anti-topoisomerase (Anti-SCL70)

A

Scleroderma, associated with ILD

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9
Q

Anti-histone

A

SLE, drug induced lupus

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10
Q

Anti-CCP

A

RA, specific

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11
Q

Rheumatoid factor

A

RA

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12
Q

Anti-thrombin

A

SLE

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13
Q

C-ANCA (PR3)

A

GPA/Wegener’s

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14
Q

P-ANCA (MPO)

A

MPA, EGPA

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15
Q

Anti-SRP

A

Polymyositis - highly aggressive, poor response to immunosuppression

Can also be seen in necrotizing autoimmune myositis

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16
Q

Anti-RNA polymerase III

A

Scleroderma, associated with renal disease

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17
Q

Anti-ro52

A

Scleroderma, ILD, dermatomyositis

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18
Q

Anti-p155

A

Dermatomyositis - Associated with malignancy, severe cutaneous involvement

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19
Q

Anti-HMGCR

A

Statin induced necrotising myositis

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20
Q

BAFF + IL6

A

GCA/PMR

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21
Q

Anti-TTG

A

Coeliac

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22
Q

Anti-etg

A

Dermatitis herpetiformis

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23
Q

Anti-actin

A

Coeliac

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24
Q

Anti-LKM-1

A

Autoimmune hepatitis

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25
Q

Anti-SMA

A

Chronic autoimmune hepatitis

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26
Q

AMA

A

Primary biliary cirrhosis

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27
Q

ASCA

A

Crohn’s

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28
Q

Anti-GQ1B

A

Miller-fischer syndrome

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29
Q

Anti GD3

A

Acute motor axonal neuropathy

30
Q

Anti GM1

A

MMN with conduction block

31
Q

Anti-AChR

A

Myasthenia gravis

32
Q

Anti-MUSK

A

Myasthenia Gravis (not seen in ocular)
Often bulbar changes
More likely to respond to rituximab
Not associated with thymoma

33
Q

Anti-LRP4

A

Myasthenia Gravis (mild-mod)

34
Q

Anti-VGCC (voltage gated calcium channel)

A

Lambert eaton myasthenic syndrome

35
Q

Anti-Hu

A

SCLC, Neuroblastomas
Paraneoplastic cerebellar degeneration, limbic encephalitis, encephalomyelitis, subacute sensory neuronopathy, choreathetosis, myoclonus

36
Q

Anti-Yo

A

Ovarian and breast ca

Paraneoplastic cerebellar degeneration

37
Q

Anti-ma

A

Testicular and lung cancer

Encephalomyelitis, Limbic encephalitis

38
Q

Anti-Ri

A

Opsoclonus myoclonus syndrome

39
Q

Anti-Tr

A

Paraneoplastic cerbellar syndrome

40
Q

Anti-amphiphysinn

A

Stiff person syndrome, paraneoplastic cerebellar degeneration

41
Q

Anti-GAD

A

T1DM

Breast, CRC, SCLC - Stiff man syndrome

42
Q

Anti-VGKC

A

Limbic encephalitis,

43
Q

Anti-CRMP-5

A

Optic neuropathy, chorea

44
Q

Anti-NMDAr

A

Anti-NMDA receptor encephalitis

45
Q

Anti-aquaporin 4

A

Neuormyelitis optica (also called Anti-NMO)

46
Q

Anti-cardiolipin

A

Antiphospholipid

47
Q

Anti beta-2-glycoprotein-1

A

Antiphospholipid

48
Q

Anti-PF4 (platelet factor 4)

A

Heparin induced thrombocytopaenia

49
Q

Anti-TPO

A

Hashimoto’s thyroiditis, Grave’s disease

50
Q

Anti-Tg

A

Hashimoto’s thyroiditis

51
Q

Anti-TRabs

A

Grave’s disease

52
Q

Anti PLA2R

A

IgG4 Ab

Membranous GN, 80% primary membranous, good response to rituximab

53
Q

Anti-THSD7A

A

Membranous GN

54
Q

suPAR (Soluble urokinase type plasminogen activator receptor)

A

Focal segmental glomerulosclerosis

55
Q

Anti-GBM

A

Goodpasture’s disease - RPGN + pulmonary haemorrhage

56
Q

c904G72

A

Frontotemporal dementia/Motor neuron disease

57
Q

Alpha synucleinopathies

A

Parkinson’s, Multisystem atrophy, DLB

58
Q

Tauopathies

A

Alzheimers, Progressive supranuclear palsy, Frontotemporal dementia

59
Q

TARDBP gene

A

FTD

60
Q

Anti-cardiolipin

A

Antiphospholipid

61
Q

Anti-PS/PT

A

Antiphospholipid, small proportion of seronegative APLS

62
Q

Anti- Mi2

A

Dermatomyositis
Shawl rash particularly
Better prognosis
Less cancer incidence

63
Q

Anti-MDA5

A

Dermatomyositis, cutaneous features predominantly

Higher risk if oral pain/ulceration, arthritis/arthralgia

64
Q

Anti-TIF1y association

A

Dermatomyositis

Strong association with malignancy

65
Q

Anti-cN1A association

A

Inclusion body myositis

66
Q

Anti-GAD65

A

T1DM

67
Q

Anti-IA-2

A

T1DM

68
Q

Anti PL7 and PL12

A

Anti-synthetase syndrome

69
Q

Anti-Ku

A

Scleroderma with myositis

70
Q

Anti-DFS70 association

A

Positive result means unlikely to be SLE

71
Q

Anti-NXP-2

Nuclear matrix protein

A

Increased risk of malignancy in dermatomyositis

Basic Physician's Training Monash (16 decks)

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